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Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition.
Eur J Clin Nutr 1996; 50(6):352-7EJ

Abstract

OBJECTIVE

To assess the effect of varying maternal intake of docosahexaenoic acid (DHA, 22 : 6n-3), in the absence of other dietary polyunsaturates, on breast milk fatty acids.

DESIGN AND INTERVENTION

Lactating mothers were randomised on day 5 post-partum to groups consuming equal numbers of capsules but containing either placebo or an oil containing DHA (43%) as its only polyunsaturate to receive 0, 0.2, 0.4, 0.9, 1.3 g DHA/day. Breast milk fatty acids as well as maternal plasma and erythrocyte phospholipids were assessed at 12 weeks post partum by capillary gas chromatography.

RESULTS

Breast milk DHA levels ranged from 0.2 to 1.7% of total fatty acids and increased in a dose dependent manner (r2 = 0.89, P < 0.01). Maternal plasma (r2 = 0.71, P < 0.01) and erythrocyte (r2 = 0.77, P < 0.01) phospholipid DHA levels increased and were also strongly associated with dietary dose of DHA. Increasing maternal dietary doses of DHA did not affect breast milk arachidonic acid (AA, 20 : 4n-6) levels or antioxidant status as measured by plasma vitamin A or E levels.

CONCLUSIONS

Our results have demonstrated that DHA in the diet has a strong, specific and dose-dependent effect on breast milk DHA.

Authors+Show Affiliations

Department of Paediatrics & Child Health, Flinders Medical Centre, Bedford Park, Adelaide, SA, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8793415

Citation

Makrides, M, et al. "Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation On Breast Milk Composition." European Journal of Clinical Nutrition, vol. 50, no. 6, 1996, pp. 352-7.
Makrides M, Neumann MA, Gibson RA. Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition. Eur J Clin Nutr. 1996;50(6):352-7.
Makrides, M., Neumann, M. A., & Gibson, R. A. (1996). Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition. European Journal of Clinical Nutrition, 50(6), pp. 352-7.
Makrides M, Neumann MA, Gibson RA. Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation On Breast Milk Composition. Eur J Clin Nutr. 1996;50(6):352-7. PubMed PMID: 8793415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition. AU - Makrides,M, AU - Neumann,M A, AU - Gibson,R A, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 352 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 50 IS - 6 N2 - OBJECTIVE: To assess the effect of varying maternal intake of docosahexaenoic acid (DHA, 22 : 6n-3), in the absence of other dietary polyunsaturates, on breast milk fatty acids. DESIGN AND INTERVENTION: Lactating mothers were randomised on day 5 post-partum to groups consuming equal numbers of capsules but containing either placebo or an oil containing DHA (43%) as its only polyunsaturate to receive 0, 0.2, 0.4, 0.9, 1.3 g DHA/day. Breast milk fatty acids as well as maternal plasma and erythrocyte phospholipids were assessed at 12 weeks post partum by capillary gas chromatography. RESULTS: Breast milk DHA levels ranged from 0.2 to 1.7% of total fatty acids and increased in a dose dependent manner (r2 = 0.89, P < 0.01). Maternal plasma (r2 = 0.71, P < 0.01) and erythrocyte (r2 = 0.77, P < 0.01) phospholipid DHA levels increased and were also strongly associated with dietary dose of DHA. Increasing maternal dietary doses of DHA did not affect breast milk arachidonic acid (AA, 20 : 4n-6) levels or antioxidant status as measured by plasma vitamin A or E levels. CONCLUSIONS: Our results have demonstrated that DHA in the diet has a strong, specific and dose-dependent effect on breast milk DHA. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/8793415/Effect_of_maternal_docosahexaenoic_acid__DHA__supplementation_on_breast_milk_composition_ L2 - https://www.lens.org/lens/search?q=citation_id:8793415 DB - PRIME DP - Unbound Medicine ER -