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Response of plasma lathosterol concentration to change in the quality of dietary fat in men and women.
Eur J Clin Nutr. 1996 Jun; 50(6):358-63.EJ

Abstract

OBJECTIVE

The aim of the study was to determine the effect of replacing saturated fatty acids (SAFA) with polyunsaturated fatty acids (PUFA) in the diet on plasma lathosterol concentration, an index of cholesterol synthesis, in mildly hypercholesterolaemic subjects.

DESIGN

The study was a randomised, cross-over trial.

SUBJECTS

Seventy-six subjects were recruited and one dropped out. Twenty-nine men and 46 women with baseline plasma cholesterol levels in the range 5.5-7.9 mmol/l were entered into the trial.

INTERVENTIONS

Subjects were placed on two isocaloric diets, one rich in SAFA and the other high in PUFA, for 6 weeks each. Plasma lathosterol and lipid and lipoprotein concentrations were measured.

RESULTS

When PUFA replaced SAFA in the diet, there was a significant (P = 0.01) fall in plasma lathosterol concentration in all subjects combined [-1.37 (-0.36 to -2.38) mumol/l] which was largely due to a significant (P = 0.03) decrease in men [-2.35 (-0.42 to -4.28) mumol/l] but not in women. The concomitant decreases in plasma cholesterol, low density lipoprotein (LDL) cholesterol and high density lipoprotein (HDL) cholesterol were similar in men and women. Plasma lathosterol concentration and the ratio lathosterol/cholesterol were significantly higher in men at baseline and during diets rich in SAFA but were not significantly different between the sexes during diets rich in PUFA.

CONCLUSIONS

These data suggest that replacing SAFA with PUFA in the diet may reduce cholesterol synthesis in mildly hypercholesterolaemic men and markedly reduce the gender-related difference in cholesterol synthesis commonly observed.

Authors+Show Affiliations

Cox CM
Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
Sutherland WH
No affiliation info available
Ball MJ
No affiliation info available
Mann JI
No affiliation info available

MeSH

AdultAgedCholesterolCholesterol, HDLCholesterol, LDLCross-Over StudiesDietary FatsFatty AcidsFatty Acids, UnsaturatedFemaleHumansMaleMiddle AgedSex Characteristics

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8793416

Citation

Cox, C M., et al. "Response of Plasma Lathosterol Concentration to Change in the Quality of Dietary Fat in Men and Women." European Journal of Clinical Nutrition, vol. 50, no. 6, 1996, pp. 358-63.
Cox CM, Sutherland WH, Ball MJ, et al. Response of plasma lathosterol concentration to change in the quality of dietary fat in men and women. Eur J Clin Nutr. 1996;50(6):358-63.
Cox, C. M., Sutherland, W. H., Ball, M. J., & Mann, J. I. (1996). Response of plasma lathosterol concentration to change in the quality of dietary fat in men and women. European Journal of Clinical Nutrition, 50(6), 358-63.
Cox CM, et al. Response of Plasma Lathosterol Concentration to Change in the Quality of Dietary Fat in Men and Women. Eur J Clin Nutr. 1996;50(6):358-63. PubMed PMID: 8793416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response of plasma lathosterol concentration to change in the quality of dietary fat in men and women. AU - Cox,C M, AU - Sutherland,W H, AU - Ball,M J, AU - Mann,J I, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 358 EP - 63 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 50 IS - 6 N2 - OBJECTIVE: The aim of the study was to determine the effect of replacing saturated fatty acids (SAFA) with polyunsaturated fatty acids (PUFA) in the diet on plasma lathosterol concentration, an index of cholesterol synthesis, in mildly hypercholesterolaemic subjects. DESIGN: The study was a randomised, cross-over trial. SUBJECTS: Seventy-six subjects were recruited and one dropped out. Twenty-nine men and 46 women with baseline plasma cholesterol levels in the range 5.5-7.9 mmol/l were entered into the trial. INTERVENTIONS: Subjects were placed on two isocaloric diets, one rich in SAFA and the other high in PUFA, for 6 weeks each. Plasma lathosterol and lipid and lipoprotein concentrations were measured. RESULTS: When PUFA replaced SAFA in the diet, there was a significant (P = 0.01) fall in plasma lathosterol concentration in all subjects combined [-1.37 (-0.36 to -2.38) mumol/l] which was largely due to a significant (P = 0.03) decrease in men [-2.35 (-0.42 to -4.28) mumol/l] but not in women. The concomitant decreases in plasma cholesterol, low density lipoprotein (LDL) cholesterol and high density lipoprotein (HDL) cholesterol were similar in men and women. Plasma lathosterol concentration and the ratio lathosterol/cholesterol were significantly higher in men at baseline and during diets rich in SAFA but were not significantly different between the sexes during diets rich in PUFA. CONCLUSIONS: These data suggest that replacing SAFA with PUFA in the diet may reduce cholesterol synthesis in mildly hypercholesterolaemic men and markedly reduce the gender-related difference in cholesterol synthesis commonly observed. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/8793416/Response_of_plasma_lathosterol_concentration_to_change_in_the_quality_of_dietary_fat_in_men_and_women_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -