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TSH and prolactin responses to thyrotropin releasing hormone (TRH) and domperidone in patients with empty sella syndrome.
J Endocrinol Invest. 1996 May; 19(5):293-7.JE

Abstract

The aim of this study was to investigate TSH and PRL response to TRH and domperidone, an antidopaminergic drug which does not cross the blood-brain barrier, in 16 patients with primary empty sella (PES) and either normal or elevated plasma PRL level and to compare it with the response observed in 8 patients with prolactinoma. In the patients with PES and hyperprolactinemia, the PRL response to TRH was significantly lower than in the controls and the patients with PES and normal PRL, which suggests there is impaired PRL synthesis and release in cases of PES with hyperprolactinemia. The TSH response to domperidone was significantly elevated in patients with PES and either normal or elevated PRL, as in patients with prolactinoma. The PRL response to domperidone was significantly reduced in patients with PES and hyperprolactinemia as in patients with prolactionoma. These results suggestthat in PES with prolactinoma the inhibiting dopaminergic tone is increased on the thyrotropic cells and reduced on the lactotropic cells in PES with elevated PRL and that some patients with PES might bear a microprolactinoma in the bottom of the sella which remained undetected by the CT scan.

Authors+Show Affiliations

Service d'Endocrinologie-Diabétologie-Nutrition, Hôpital Jean Verdier, Bondy, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8796337

Citation

Valensi, P, et al. "TSH and Prolactin Responses to Thyrotropin Releasing Hormone (TRH) and Domperidone in Patients With Empty Sella Syndrome." Journal of Endocrinological Investigation, vol. 19, no. 5, 1996, pp. 293-7.
Valensi P, Combes ME, Perret G, et al. TSH and prolactin responses to thyrotropin releasing hormone (TRH) and domperidone in patients with empty sella syndrome. J Endocrinol Invest. 1996;19(5):293-7.
Valensi, P., Combes, M. E., Perret, G., & Attali, J. R. (1996). TSH and prolactin responses to thyrotropin releasing hormone (TRH) and domperidone in patients with empty sella syndrome. Journal of Endocrinological Investigation, 19(5), 293-7.
Valensi P, et al. TSH and Prolactin Responses to Thyrotropin Releasing Hormone (TRH) and Domperidone in Patients With Empty Sella Syndrome. J Endocrinol Invest. 1996;19(5):293-7. PubMed PMID: 8796337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TSH and prolactin responses to thyrotropin releasing hormone (TRH) and domperidone in patients with empty sella syndrome. AU - Valensi,P, AU - Combes,M E, AU - Perret,G, AU - Attali,J R, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 293 EP - 7 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 19 IS - 5 N2 - The aim of this study was to investigate TSH and PRL response to TRH and domperidone, an antidopaminergic drug which does not cross the blood-brain barrier, in 16 patients with primary empty sella (PES) and either normal or elevated plasma PRL level and to compare it with the response observed in 8 patients with prolactinoma. In the patients with PES and hyperprolactinemia, the PRL response to TRH was significantly lower than in the controls and the patients with PES and normal PRL, which suggests there is impaired PRL synthesis and release in cases of PES with hyperprolactinemia. The TSH response to domperidone was significantly elevated in patients with PES and either normal or elevated PRL, as in patients with prolactinoma. The PRL response to domperidone was significantly reduced in patients with PES and hyperprolactinemia as in patients with prolactionoma. These results suggestthat in PES with prolactinoma the inhibiting dopaminergic tone is increased on the thyrotropic cells and reduced on the lactotropic cells in PES with elevated PRL and that some patients with PES might bear a microprolactinoma in the bottom of the sella which remained undetected by the CT scan. SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/8796337/TSH_and_prolactin_responses_to_thyrotropin_releasing_hormone__TRH__and_domperidone_in_patients_with_empty_sella_syndrome_ L2 - https://link.springer.com/article/10.1007/BF03347865 DB - PRIME DP - Unbound Medicine ER -