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Anatomical variation of the oestrogen receptor in the non-neoplastic myometrium of fibromyomatous uteri.
Virchows Arch. 1996 Aug; 428(6):347-51.VA

Abstract

Myometrial tissues from a total of 30 normal and 30 fibromyomatous uteri were compared in order to assess whether the oestrogen receptor distribution is similar for both types. All patients concerned were premenopausal with no history of exogenous hormone usage. Material taken from the subserosal, midmyometrial and subendometrial regions of both the fundus and the lower segment was stained by immunocytochemistry for the oestrogen receptor. No significant difference in the oestrogen receptor content was noted between the fundus and the lower segment in either the normal or the fibromyomatous myometria. Similarly, the phase of the menstrual cycle did not affect the total receptor content of either group of tissue. The oestrogen receptor content in the non-neoplastic portion of the fibromyomatous myometria was highest in the subendometrial and lowest in the subserosal region. The differences in receptor content between normal and fibromyomatous myometria were minimal in the subendometrial region but marked in the subserosal region. The myometrium of fibromyomatous uteri thus expresses significantly increased levels of oestrogen receptor, and the pathogenesis of fibromyomata may be related to an inherent abnormality in the myometrium.

Authors+Show Affiliations

Richards PA
Department of Anatomical Pathology, Medical School, University of Cape Town, South Africa.
Tiltman AJ
No affiliation info available

MeSH

AdultAnalysis of VarianceCell CountFemaleHumansHysterectomyImmunohistochemistryLeiomyomaMenstrual CycleMiddle AgedMyometriumReceptors, EstrogenReference ValuesUterus

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8797938

Citation

Richards, P A., and A J. Tiltman. "Anatomical Variation of the Oestrogen Receptor in the Non-neoplastic Myometrium of Fibromyomatous Uteri." Virchows Archiv : an International Journal of Pathology, vol. 428, no. 6, 1996, pp. 347-51.
Richards PA, Tiltman AJ. Anatomical variation of the oestrogen receptor in the non-neoplastic myometrium of fibromyomatous uteri. Virchows Arch. 1996;428(6):347-51.
Richards, P. A., & Tiltman, A. J. (1996). Anatomical variation of the oestrogen receptor in the non-neoplastic myometrium of fibromyomatous uteri. Virchows Archiv : an International Journal of Pathology, 428(6), 347-51.
Richards PA, Tiltman AJ. Anatomical Variation of the Oestrogen Receptor in the Non-neoplastic Myometrium of Fibromyomatous Uteri. Virchows Arch. 1996;428(6):347-51. PubMed PMID: 8797938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anatomical variation of the oestrogen receptor in the non-neoplastic myometrium of fibromyomatous uteri. AU - Richards,P A, AU - Tiltman,A J, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 347 EP - 51 JF - Virchows Archiv : an international journal of pathology JO - Virchows Arch VL - 428 IS - 6 N2 - Myometrial tissues from a total of 30 normal and 30 fibromyomatous uteri were compared in order to assess whether the oestrogen receptor distribution is similar for both types. All patients concerned were premenopausal with no history of exogenous hormone usage. Material taken from the subserosal, midmyometrial and subendometrial regions of both the fundus and the lower segment was stained by immunocytochemistry for the oestrogen receptor. No significant difference in the oestrogen receptor content was noted between the fundus and the lower segment in either the normal or the fibromyomatous myometria. Similarly, the phase of the menstrual cycle did not affect the total receptor content of either group of tissue. The oestrogen receptor content in the non-neoplastic portion of the fibromyomatous myometria was highest in the subendometrial and lowest in the subserosal region. The differences in receptor content between normal and fibromyomatous myometria were minimal in the subendometrial region but marked in the subserosal region. The myometrium of fibromyomatous uteri thus expresses significantly increased levels of oestrogen receptor, and the pathogenesis of fibromyomata may be related to an inherent abnormality in the myometrium. SN - 0945-6317 UR - https://www.unboundmedicine.com/medline/citation/8797938/Anatomical_variation_of_the_oestrogen_receptor_in_the_non_neoplastic_myometrium_of_fibromyomatous_uteri_ DB - PRIME DP - Unbound Medicine ER -