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Helicobacter pylori transmission: evidence from a comparison with hepatitis A virus.
Eur J Gastroenterol Hepatol. 1996 May; 8(5):439-41.EJ

Abstract

OBJECTIVE

To assess the possibility that faecal-oral contact might play a role in the transmission of Helicobacter pylori.

DESIGN

A cross-sectional comparison of the patterns of hepatitis A and H. pylori seropositivity.

METHODS

At interview, blood samples and questionnaire data were collected from a group of 467 male volunteers, aged 18-65, from Stoke-on-Trent, UK. Serum samples from each subject were then analysed for anti-H. pylori and anti-hepatitis A antibodies.

RESULTS

Overall, 100 of 175 H. pylori seropositive subjects (57.1%) and 113 of 292 H. pylori seronegative subjects (38.7%) were hepatitis A seropositive (chi 2 = 15.0, P < 0.001). This difference was not statistically significant after adjustment for age group and father's occupation, as a surrogate for socioeconomic status in childhood (P = 0.15). The seroprevalence of hepatitis A increased with age at a rate of 2.3% per year, compared to only 1.0% per year for H. pylori (P = 0.015).

CONCLUSION

These data suggest that the case for faecal-oral transmission of H. pylori, in a manner similar to the spread of hepatitis A, is not proven and that other modes of transmission, for instance through oral-oral contact, should also be considered.

Authors+Show Affiliations

Imperial Cancer Research Fund, Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8804871

Citation

Webb, P M., et al. "Helicobacter Pylori Transmission: Evidence From a Comparison With Hepatitis a Virus." European Journal of Gastroenterology & Hepatology, vol. 8, no. 5, 1996, pp. 439-41.
Webb PM, Knight T, Newell DG, et al. Helicobacter pylori transmission: evidence from a comparison with hepatitis A virus. Eur J Gastroenterol Hepatol. 1996;8(5):439-41.
Webb, P. M., Knight, T., Newell, D. G., Elder, J. B., & Forman, D. (1996). Helicobacter pylori transmission: evidence from a comparison with hepatitis A virus. European Journal of Gastroenterology & Hepatology, 8(5), 439-41.
Webb PM, et al. Helicobacter Pylori Transmission: Evidence From a Comparison With Hepatitis a Virus. Eur J Gastroenterol Hepatol. 1996;8(5):439-41. PubMed PMID: 8804871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori transmission: evidence from a comparison with hepatitis A virus. AU - Webb,P M, AU - Knight,T, AU - Newell,D G, AU - Elder,J B, AU - Forman,D, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 439 EP - 41 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 8 IS - 5 N2 - OBJECTIVE: To assess the possibility that faecal-oral contact might play a role in the transmission of Helicobacter pylori. DESIGN: A cross-sectional comparison of the patterns of hepatitis A and H. pylori seropositivity. METHODS: At interview, blood samples and questionnaire data were collected from a group of 467 male volunteers, aged 18-65, from Stoke-on-Trent, UK. Serum samples from each subject were then analysed for anti-H. pylori and anti-hepatitis A antibodies. RESULTS: Overall, 100 of 175 H. pylori seropositive subjects (57.1%) and 113 of 292 H. pylori seronegative subjects (38.7%) were hepatitis A seropositive (chi 2 = 15.0, P < 0.001). This difference was not statistically significant after adjustment for age group and father's occupation, as a surrogate for socioeconomic status in childhood (P = 0.15). The seroprevalence of hepatitis A increased with age at a rate of 2.3% per year, compared to only 1.0% per year for H. pylori (P = 0.015). CONCLUSION: These data suggest that the case for faecal-oral transmission of H. pylori, in a manner similar to the spread of hepatitis A, is not proven and that other modes of transmission, for instance through oral-oral contact, should also be considered. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/8804871/Helicobacter_pylori_transmission:_evidence_from_a_comparison_with_hepatitis_A_virus_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -