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Influence of pattern of clinical presentation and of gluten-free diet on bone mass and metabolism in adult coeliac disease.
Bone 1996; 18(6):525-30BONE

Abstract

Since no information is available on bone derangements in subclinical coeliac disease (CD), we evaluated bone mineral density (BMD, expressed as z score) at lumbar spine, by X-ray dual-photon absorptiometry, and serum indices of bone metabolism and remodeling in 14 subclinical or silent patients, 10 classical patients, and 15 healthy volunteers all on a gluten-containing diet. In the subclinical group, BMD at lumbar spine was significantly higher than in the classical group (-1.3 +/- 0.8, 73% vs. -2.6 +/- 0.6, 88%, respectively; p < 0.001), but significantly lower than in volunteers (+0.4 +/- 1.1, 104%; p < 0.001). Similar changes were observed in serum calcium, whereas, as regards parathyroid hormone, no significant difference was found between subclinical and classical patients. 25-vitamin D was significantly lower, and 1,25-vitamin D was significantly higher in subclinical and classical patients than in healthy volunteers. Indices of bone remodeling were higher in the subclinical and classical groups than in the volunteers, but lower in the subclinical than in classical patients. Eight subclinical and 8 classical patients were reexamined after a period of gluten-free diet (GFD), and in both groups BMD had significantly improved. Our results show that osteopenia is a frequent feature also in subclinical CD, although the extent of bone and mineral metabolism derangements is lower than in classical CD. GFD is able to normalize BMD in subclinical and to significantly improve it in classical patients.

Authors+Show Affiliations

Department of Internal Medicine, University of L'Aquila, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8805992

Citation

Corazza, G R., et al. "Influence of Pattern of Clinical Presentation and of Gluten-free Diet On Bone Mass and Metabolism in Adult Coeliac Disease." Bone, vol. 18, no. 6, 1996, pp. 525-30.
Corazza GR, Di Sario A, Cecchetti L, et al. Influence of pattern of clinical presentation and of gluten-free diet on bone mass and metabolism in adult coeliac disease. Bone. 1996;18(6):525-30.
Corazza, G. R., Di Sario, A., Cecchetti, L., Jorizzo, R. A., Di Stefano, M., Minguzzi, L., ... Gasbarrini, G. (1996). Influence of pattern of clinical presentation and of gluten-free diet on bone mass and metabolism in adult coeliac disease. Bone, 18(6), pp. 525-30.
Corazza GR, et al. Influence of Pattern of Clinical Presentation and of Gluten-free Diet On Bone Mass and Metabolism in Adult Coeliac Disease. Bone. 1996;18(6):525-30. PubMed PMID: 8805992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of pattern of clinical presentation and of gluten-free diet on bone mass and metabolism in adult coeliac disease. AU - Corazza,G R, AU - Di Sario,A, AU - Cecchetti,L, AU - Jorizzo,R A, AU - Di Stefano,M, AU - Minguzzi,L, AU - Brusco,G, AU - Bernardi,M, AU - Gasbarrini,G, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 525 EP - 30 JF - Bone JO - Bone VL - 18 IS - 6 N2 - Since no information is available on bone derangements in subclinical coeliac disease (CD), we evaluated bone mineral density (BMD, expressed as z score) at lumbar spine, by X-ray dual-photon absorptiometry, and serum indices of bone metabolism and remodeling in 14 subclinical or silent patients, 10 classical patients, and 15 healthy volunteers all on a gluten-containing diet. In the subclinical group, BMD at lumbar spine was significantly higher than in the classical group (-1.3 +/- 0.8, 73% vs. -2.6 +/- 0.6, 88%, respectively; p < 0.001), but significantly lower than in volunteers (+0.4 +/- 1.1, 104%; p < 0.001). Similar changes were observed in serum calcium, whereas, as regards parathyroid hormone, no significant difference was found between subclinical and classical patients. 25-vitamin D was significantly lower, and 1,25-vitamin D was significantly higher in subclinical and classical patients than in healthy volunteers. Indices of bone remodeling were higher in the subclinical and classical groups than in the volunteers, but lower in the subclinical than in classical patients. Eight subclinical and 8 classical patients were reexamined after a period of gluten-free diet (GFD), and in both groups BMD had significantly improved. Our results show that osteopenia is a frequent feature also in subclinical CD, although the extent of bone and mineral metabolism derangements is lower than in classical CD. GFD is able to normalize BMD in subclinical and to significantly improve it in classical patients. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/8805992/Influence_of_pattern_of_clinical_presentation_and_of_gluten_free_diet_on_bone_mass_and_metabolism_in_adult_coeliac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/8756328296000713 DB - PRIME DP - Unbound Medicine ER -