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Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast.
Diagn Cytopathol. 1996 Jul; 15(1):1-6.DC

Abstract

Metastatic ovarian carcinoma to the breast is rare. It represents a diagnostic challenge to the cytologist. It usually signifies a progressive widespread metastatic ovarian tumor with a poor prognosis. This report evaluates the breast fine-needle aspiration (FNA) cytomorphologic features of six cases of metastatic ovarian carcinoma and compares them to those reported in the literature. The cytologic features included hypercellularity, abundant papillary fragments, and necrotic background. The tumor cells showed high nuclear/cytoplasmic ratio, anisonucleosis, prominent nucleoli, and psammoma bodies in cases of serous papillary carcinoma. In addition, the clear-cell carcinoma had prominent finely vacuolated and clear cytoplasm, multinucleated giant cells, and papillary fragments with hobnail nuclei. Recognition of these unusual patterns in a breast FNA cytology should raise the suspicion of a metastatic ovarian tumor. Direct comparison between the breast FNA cytology and the original primary ovarian tumor should confirm the diagnosis. The proper diagnosis of metastatic ovarian cancer to the breast will prevent unnecessary surgical treatment and ensure the appropriate therapy.

Authors+Show Affiliations

Department of Pathology, St. Mary's Hospital, Montreal, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8807244

Citation

Raptis, S, et al. "Fine-needle Aspiration Cytology of Metastatic Ovarian Carcinoma to the Breast." Diagnostic Cytopathology, vol. 15, no. 1, 1996, pp. 1-6.
Raptis S, Kanbour AI, Dusenbery D, et al. Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast. Diagn Cytopathol. 1996;15(1):1-6.
Raptis, S., Kanbour, A. I., Dusenbery, D., & Kanbour-Shakir, A. (1996). Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast. Diagnostic Cytopathology, 15(1), 1-6.
Raptis S, et al. Fine-needle Aspiration Cytology of Metastatic Ovarian Carcinoma to the Breast. Diagn Cytopathol. 1996;15(1):1-6. PubMed PMID: 8807244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast. AU - Raptis,S, AU - Kanbour,A I, AU - Dusenbery,D, AU - Kanbour-Shakir,A, PY - 1996/7/1/pubmed PY - 2000/6/22/medline PY - 1996/7/1/entrez SP - 1 EP - 6 JF - Diagnostic cytopathology JO - Diagn Cytopathol VL - 15 IS - 1 N2 - Metastatic ovarian carcinoma to the breast is rare. It represents a diagnostic challenge to the cytologist. It usually signifies a progressive widespread metastatic ovarian tumor with a poor prognosis. This report evaluates the breast fine-needle aspiration (FNA) cytomorphologic features of six cases of metastatic ovarian carcinoma and compares them to those reported in the literature. The cytologic features included hypercellularity, abundant papillary fragments, and necrotic background. The tumor cells showed high nuclear/cytoplasmic ratio, anisonucleosis, prominent nucleoli, and psammoma bodies in cases of serous papillary carcinoma. In addition, the clear-cell carcinoma had prominent finely vacuolated and clear cytoplasm, multinucleated giant cells, and papillary fragments with hobnail nuclei. Recognition of these unusual patterns in a breast FNA cytology should raise the suspicion of a metastatic ovarian tumor. Direct comparison between the breast FNA cytology and the original primary ovarian tumor should confirm the diagnosis. The proper diagnosis of metastatic ovarian cancer to the breast will prevent unnecessary surgical treatment and ensure the appropriate therapy. SN - 8755-1039 UR - https://www.unboundmedicine.com/medline/citation/8807244/Fine_needle_aspiration_cytology_of_metastatic_ovarian_carcinoma_to_the_breast_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=8755-1039&date=1996&volume=15&issue=1&spage=1 DB - PRIME DP - Unbound Medicine ER -