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Changes of bone markers during long-term intravenous calcitriol therapy in maintenance dialysis patients.
Miner Electrolyte Metab 1996; 22(4):219-23ME

Abstract

Twenty patients with end-stage renal failure on maintenance hemodialysis were studied for the effect of intravenous 1,25(OH)2 vitamin D3 on biochemical bone markers. Active vitamin D, 1,25(OH)2 vitamin D3, was given intravenously after hemodialysis, 1 microgram thrice weekly. Serum ionized calcium, phosphorus, alkaline phosphatase (AKPase), intact parathyroid hormone (PTH), osteocalcin (bone Gla protein), carboxy terminal propeptide of type I procollagen (PICP), cross-linked telopeptide of type I collagen (ICTP) and beta 2-microglobulin were measured before and after 3 and 6 months of treatment with 1,25(OH)2 vitamin D3. The serum ionized calcium and osteocalcin levels were significantly increased at 3 and 6 months after treatment. The serum beta 2-microglobulin level were also increased 6 months after treatment, whereas the serum levels of AKPase and intact PTH decreased after treatment. However, the serum levels of phosphorus, PICP and ICTP did not change significantly after treatment. The decreased levels of serum AKPase and intact PTH suggest reduced bone resorption. Increases of serum osteocalcin levels were caused by stimulation of the osteoblast by 1,25(OH)2 vitamin D3, baseline 20.6 +/- 12.5 micrograms/l, and 36.1 +/- 34.0 and 31.0 +/- 24.6 micrograms/l at 3 and 6 months, respectively (p < 0.01). The lower osteocalcin level at 6 rather than at 3 months may imply reduced bone resorption and/or increased bone mineralization. The meaning of the increase of serum beta 2-microglobulin in uremic patients after calcitriol treatment is unclear. It may indicate reduced deposition and is masked by increased bone resorption from secondary or tertiary hyperparathyroidism. This study did not validate PICP and ICTP measurements as bone markers in uremic patients.

Authors+Show Affiliations

Department of Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8807625

Citation

Lee, S H., et al. "Changes of Bone Markers During Long-term Intravenous Calcitriol Therapy in Maintenance Dialysis Patients." Mineral and Electrolyte Metabolism, vol. 22, no. 4, 1996, pp. 219-23.
Lee SH, Huang TS, Hsieh SJ. Changes of bone markers during long-term intravenous calcitriol therapy in maintenance dialysis patients. Miner Electrolyte Metab. 1996;22(4):219-23.
Lee, S. H., Huang, T. S., & Hsieh, S. J. (1996). Changes of bone markers during long-term intravenous calcitriol therapy in maintenance dialysis patients. Mineral and Electrolyte Metabolism, 22(4), pp. 219-23.
Lee SH, Huang TS, Hsieh SJ. Changes of Bone Markers During Long-term Intravenous Calcitriol Therapy in Maintenance Dialysis Patients. Miner Electrolyte Metab. 1996;22(4):219-23. PubMed PMID: 8807625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes of bone markers during long-term intravenous calcitriol therapy in maintenance dialysis patients. AU - Lee,S H, AU - Huang,T S, AU - Hsieh,S J, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 219 EP - 23 JF - Mineral and electrolyte metabolism JO - Miner Electrolyte Metab VL - 22 IS - 4 N2 - Twenty patients with end-stage renal failure on maintenance hemodialysis were studied for the effect of intravenous 1,25(OH)2 vitamin D3 on biochemical bone markers. Active vitamin D, 1,25(OH)2 vitamin D3, was given intravenously after hemodialysis, 1 microgram thrice weekly. Serum ionized calcium, phosphorus, alkaline phosphatase (AKPase), intact parathyroid hormone (PTH), osteocalcin (bone Gla protein), carboxy terminal propeptide of type I procollagen (PICP), cross-linked telopeptide of type I collagen (ICTP) and beta 2-microglobulin were measured before and after 3 and 6 months of treatment with 1,25(OH)2 vitamin D3. The serum ionized calcium and osteocalcin levels were significantly increased at 3 and 6 months after treatment. The serum beta 2-microglobulin level were also increased 6 months after treatment, whereas the serum levels of AKPase and intact PTH decreased after treatment. However, the serum levels of phosphorus, PICP and ICTP did not change significantly after treatment. The decreased levels of serum AKPase and intact PTH suggest reduced bone resorption. Increases of serum osteocalcin levels were caused by stimulation of the osteoblast by 1,25(OH)2 vitamin D3, baseline 20.6 +/- 12.5 micrograms/l, and 36.1 +/- 34.0 and 31.0 +/- 24.6 micrograms/l at 3 and 6 months, respectively (p < 0.01). The lower osteocalcin level at 6 rather than at 3 months may imply reduced bone resorption and/or increased bone mineralization. The meaning of the increase of serum beta 2-microglobulin in uremic patients after calcitriol treatment is unclear. It may indicate reduced deposition and is masked by increased bone resorption from secondary or tertiary hyperparathyroidism. This study did not validate PICP and ICTP measurements as bone markers in uremic patients. SN - 0378-0392 UR - https://www.unboundmedicine.com/medline/citation/8807625/Changes_of_bone_markers_during_long_term_intravenous_calcitriol_therapy_in_maintenance_dialysis_patients_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -