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Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles.
Acta Neuropathol. 1996 Jul; 92(1):42-8.AN

Abstract

Alzheimer's disease (AD) is characterised neuropathologically by the presence of abundant extracellular beta-amyloid deposits and intracellular neurofibrillary lesions consisting of neurofibrillary tangles, neuropil threads and senile plaque neurites which contain paired helical filaments (PHFs) made of hyperphosphorylated microtubule-associated protein tau. A new familial form of presenile dementia with neurofibrillary pathology and no beta-amyloid deposits has been described recently [Sumi et al. (1992) Neurology 42: 120-127]. We have compared the tau pathology in this familial form of presenile dementia with that of AD. To this end we have used electron microscopy, immunoblotting and immunohistochemistry with phosphorylation-dependent (PHF1, AT8, AT100, AT180, AT270, 12E8) and phosphorylation-independent (BR133, BR134) anti-tau antibodies. We show that in the two diseases dispersed PHFs are structurally, biochemically and immunologically identical; they are stained by all anti-tau antibodies used and on immunoblots PHF-tau appears as three major bands of 60, 64 and 68 kDa. However, while the anti-tau antibodies stain neurofibrillary tangles, neuropil threads and neuritic plaques in AD brain, no neuritic plaques are found in familial presenile dementia. These results indicate that in the two diseases tau undergoes the same modifications; they confirm that neurofibrillary tangles and neuropil threads like those in AD can exist independently of beta-amyloid deposits and that their presence is associated with dementia.

Authors+Show Affiliations

MRC Laboratory of Molecular Biology, Cambridge, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8811124

Citation

Spillantini, M G., et al. "Comparison of the Neurofibrillary Pathology in Alzheimer's Disease and Familial Presenile Dementia With Tangles." Acta Neuropathologica, vol. 92, no. 1, 1996, pp. 42-8.
Spillantini MG, Crowther RA, Goedert M. Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles. Acta Neuropathol. 1996;92(1):42-8.
Spillantini, M. G., Crowther, R. A., & Goedert, M. (1996). Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles. Acta Neuropathologica, 92(1), 42-8.
Spillantini MG, Crowther RA, Goedert M. Comparison of the Neurofibrillary Pathology in Alzheimer's Disease and Familial Presenile Dementia With Tangles. Acta Neuropathol. 1996;92(1):42-8. PubMed PMID: 8811124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles. AU - Spillantini,M G, AU - Crowther,R A, AU - Goedert,M, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 42 EP - 8 JF - Acta neuropathologica JO - Acta Neuropathol VL - 92 IS - 1 N2 - Alzheimer's disease (AD) is characterised neuropathologically by the presence of abundant extracellular beta-amyloid deposits and intracellular neurofibrillary lesions consisting of neurofibrillary tangles, neuropil threads and senile plaque neurites which contain paired helical filaments (PHFs) made of hyperphosphorylated microtubule-associated protein tau. A new familial form of presenile dementia with neurofibrillary pathology and no beta-amyloid deposits has been described recently [Sumi et al. (1992) Neurology 42: 120-127]. We have compared the tau pathology in this familial form of presenile dementia with that of AD. To this end we have used electron microscopy, immunoblotting and immunohistochemistry with phosphorylation-dependent (PHF1, AT8, AT100, AT180, AT270, 12E8) and phosphorylation-independent (BR133, BR134) anti-tau antibodies. We show that in the two diseases dispersed PHFs are structurally, biochemically and immunologically identical; they are stained by all anti-tau antibodies used and on immunoblots PHF-tau appears as three major bands of 60, 64 and 68 kDa. However, while the anti-tau antibodies stain neurofibrillary tangles, neuropil threads and neuritic plaques in AD brain, no neuritic plaques are found in familial presenile dementia. These results indicate that in the two diseases tau undergoes the same modifications; they confirm that neurofibrillary tangles and neuropil threads like those in AD can exist independently of beta-amyloid deposits and that their presence is associated with dementia. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/8811124/Comparison_of_the_neurofibrillary_pathology_in_Alzheimer's_disease_and_familial_presenile_dementia_with_tangles_ L2 - https://dx.doi.org/10.1007/s004010050487 DB - PRIME DP - Unbound Medicine ER -