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Clinical and pH-metric characteristics of gastro-oesophageal reflux secondary to cows' milk protein allergy.
Arch Dis Child 1996; 75(1):51-6AD

Abstract

AIMS

The primary aim was to assess whether there were differences in symptoms, laboratory data, and oesophageal pH-metry between infants with primary gastro-oesophageal reflux and those with reflux secondary to cows' milk protein allergy (CMPA).

PATIENTS AND METHODS

96 infants (mean(SD) age 7.8(2.0) months) with either primary gastro-oesophageal reflux, reflux with CMPA, CMPA only, or none of these (controls) were studied. Symptoms, immunochemical data, and oesophageal pH were compared between the four groups and the effect of a cows' milk protein-free diet on the severity of symptoms was also assessed.

RESULTS

14 out of 47(30%) infants with gastro-oesophageal reflux had CMPA. These infants had similar symptoms to those with primary gastro-oesophageal reflux but higher concentrations of total IgE and circulating eosinophils (p < 0.005) and IgG anti-beta lactoglobulin (p < 0.003). A progressive constant reduction in oesophageal pH at the end of a feed, which continued up to the next feed, was seen in 12 out of 14 patients with gastro-oesophageal reflux secondary to CMPA and in 24 of 25 infants with CMPA only. No infants with primary gastro-oesophageal reflux and none of the controls had this pattern. A cows' milk protein-free diet was associated with a significant improvement in symptoms only in infants with gastro-oesophageal reflux with CMPA.

CONCLUSION

A characteristic oesophageal pH pattern is useful in distinguishing infants with gastro-oesophageal reflux associated with CMPA.

Authors+Show Affiliations

Division of Paediatrics II, Ospedale Di Cristina, Palermo, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8813871

Citation

Cavataio, F, et al. "Clinical and pH-metric Characteristics of Gastro-oesophageal Reflux Secondary to Cows' Milk Protein Allergy." Archives of Disease in Childhood, vol. 75, no. 1, 1996, pp. 51-6.
Cavataio F, Iacono G, Montalto G, et al. Clinical and pH-metric characteristics of gastro-oesophageal reflux secondary to cows' milk protein allergy. Arch Dis Child. 1996;75(1):51-6.
Cavataio, F., Iacono, G., Montalto, G., Soresi, M., Tumminello, M., & Carroccio, A. (1996). Clinical and pH-metric characteristics of gastro-oesophageal reflux secondary to cows' milk protein allergy. Archives of Disease in Childhood, 75(1), pp. 51-6.
Cavataio F, et al. Clinical and pH-metric Characteristics of Gastro-oesophageal Reflux Secondary to Cows' Milk Protein Allergy. Arch Dis Child. 1996;75(1):51-6. PubMed PMID: 8813871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and pH-metric characteristics of gastro-oesophageal reflux secondary to cows' milk protein allergy. AU - Cavataio,F, AU - Iacono,G, AU - Montalto,G, AU - Soresi,M, AU - Tumminello,M, AU - Carroccio,A, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 51 EP - 6 JF - Archives of disease in childhood JO - Arch. Dis. Child. VL - 75 IS - 1 N2 - AIMS: The primary aim was to assess whether there were differences in symptoms, laboratory data, and oesophageal pH-metry between infants with primary gastro-oesophageal reflux and those with reflux secondary to cows' milk protein allergy (CMPA). PATIENTS AND METHODS: 96 infants (mean(SD) age 7.8(2.0) months) with either primary gastro-oesophageal reflux, reflux with CMPA, CMPA only, or none of these (controls) were studied. Symptoms, immunochemical data, and oesophageal pH were compared between the four groups and the effect of a cows' milk protein-free diet on the severity of symptoms was also assessed. RESULTS: 14 out of 47(30%) infants with gastro-oesophageal reflux had CMPA. These infants had similar symptoms to those with primary gastro-oesophageal reflux but higher concentrations of total IgE and circulating eosinophils (p < 0.005) and IgG anti-beta lactoglobulin (p < 0.003). A progressive constant reduction in oesophageal pH at the end of a feed, which continued up to the next feed, was seen in 12 out of 14 patients with gastro-oesophageal reflux secondary to CMPA and in 24 of 25 infants with CMPA only. No infants with primary gastro-oesophageal reflux and none of the controls had this pattern. A cows' milk protein-free diet was associated with a significant improvement in symptoms only in infants with gastro-oesophageal reflux with CMPA. CONCLUSION: A characteristic oesophageal pH pattern is useful in distinguishing infants with gastro-oesophageal reflux associated with CMPA. SN - 1468-2044 UR - https://www.unboundmedicine.com/medline/citation/8813871/Clinical_and_pH_metric_characteristics_of_gastro_oesophageal_reflux_secondary_to_cows'_milk_protein_allergy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8813871.ui DB - PRIME DP - Unbound Medicine ER -