Tags

Type your tag names separated by a space and hit enter

Effect of food composition on vitamin K absorption in human volunteers.

Abstract

The human vitamin K requirement is not known precisely, but the minimal requirement is often assumed to be between 0.5 and 1 x 10(-6) g/kg body weight. In the present study we addressed the question to what extent circulating vitamin K concentrations are influenced by the form in which the vitamer is consumed. The experimental group consisted of five healthy volunteers who received phylloquinone after an overnight fast. On the first day of three successive weeks the participants consumed 1 mg (2.2 mumol) phylloquinone, either in the form of a pharmaceutical preparation (Konakion), or in the form of spinach + butter, or as spinach without added fat. Circulating phylloquinone levels after spinach with and without butter were substantially lower (7.5- and 24.3-fold respectively) than those after taking the pharmaceutical concentrate. Moreover, the absorption of phylloquinone from the vegetables was 1.5 times slower than from Konakion. In a second experiment in the same five volunteers it was shown that relatively high amounts of menaquinone-4 enter the circulation after the consumption of butter enriched with this vitamer. It is concluded that the bioavailability of membrane-bound phylloquinone is extremely poor and may depend on other food components, notably fat. The bioavailability of dietary vitamin K (phylloquinone + menaquinones) is lower than generally assumed, and depends on the form in which the vitamin is ingested. These new insights may lead to a revision of the recommended daily intake for vitamin K.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Biochemistry, University of Limburg, Maastrict, The Netherlands.

    ,

    Source

    The British journal of nutrition 76:2 1996 Aug pg 223-9

    MeSH

    Adult
    Biological Availability
    Butter
    Female
    Food
    Hemostatics
    Humans
    Intestinal Absorption
    Male
    Middle Aged
    Spinacia oleracea
    Vitamin K
    Vitamin K 1
    Vitamin K 2

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    8813897

    Citation

    Gijsbers, B L., et al. "Effect of Food Composition On Vitamin K Absorption in Human Volunteers." The British Journal of Nutrition, vol. 76, no. 2, 1996, pp. 223-9.
    Gijsbers BL, Jie KS, Vermeer C. Effect of food composition on vitamin K absorption in human volunteers. Br J Nutr. 1996;76(2):223-9.
    Gijsbers, B. L., Jie, K. S., & Vermeer, C. (1996). Effect of food composition on vitamin K absorption in human volunteers. The British Journal of Nutrition, 76(2), pp. 223-9.
    Gijsbers BL, Jie KS, Vermeer C. Effect of Food Composition On Vitamin K Absorption in Human Volunteers. Br J Nutr. 1996;76(2):223-9. PubMed PMID: 8813897.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of food composition on vitamin K absorption in human volunteers. AU - Gijsbers,B L, AU - Jie,K S, AU - Vermeer,C, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 223 EP - 9 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 76 IS - 2 N2 - The human vitamin K requirement is not known precisely, but the minimal requirement is often assumed to be between 0.5 and 1 x 10(-6) g/kg body weight. In the present study we addressed the question to what extent circulating vitamin K concentrations are influenced by the form in which the vitamer is consumed. The experimental group consisted of five healthy volunteers who received phylloquinone after an overnight fast. On the first day of three successive weeks the participants consumed 1 mg (2.2 mumol) phylloquinone, either in the form of a pharmaceutical preparation (Konakion), or in the form of spinach + butter, or as spinach without added fat. Circulating phylloquinone levels after spinach with and without butter were substantially lower (7.5- and 24.3-fold respectively) than those after taking the pharmaceutical concentrate. Moreover, the absorption of phylloquinone from the vegetables was 1.5 times slower than from Konakion. In a second experiment in the same five volunteers it was shown that relatively high amounts of menaquinone-4 enter the circulation after the consumption of butter enriched with this vitamer. It is concluded that the bioavailability of membrane-bound phylloquinone is extremely poor and may depend on other food components, notably fat. The bioavailability of dietary vitamin K (phylloquinone + menaquinones) is lower than generally assumed, and depends on the form in which the vitamin is ingested. These new insights may lead to a revision of the recommended daily intake for vitamin K. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/8813897/Effect_of_food_composition_on_vitamin_K_absorption_in_human_volunteers_ L2 - https://www.cambridge.org/core/product/identifier/S0007114596001304/type/journal_article DB - PRIME DP - Unbound Medicine ER -