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The absence of an effect of food on the bioavailability of azithromycin administered as tablets, sachet or suspension.
J Antimicrob Chemother. 1996 Jun; 37 Suppl C:37-44.JA

Abstract

Present product labelling indicates that azithromycin capsules should not be taken with food. However, three recent studies demonstrated that food does not significantly decrease the bioavilabilities of three new formulations of azithromycin (250 mg tablets, 1000 mg sachet, 500 mg paediatric suspension). With a 500 mg dosage, the mean relative bioavailability of azithromycin following ingestion of a standard high-fat breakfast was 96% when administered as two 250 mg tablets and 113% when administered as a suspension. The mean relative bioavailability of a 1000 mg sachet was 112%. The absolute bioavailability of the sachet formulation, relative to a 1 h iv infusion of 1000 mg, was 44%. Thus, azithromycin tablets, suspension and sachet may be given without regard to meals, further enhancing the convenience of once-daily, short-duration dosing regimens.

Authors+Show Affiliations

Central Research Division, Pfizer Inc., Groton, CT 06340, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8818844

Citation

Foulds, G, et al. "The Absence of an Effect of Food On the Bioavailability of Azithromycin Administered as Tablets, Sachet or Suspension." The Journal of Antimicrobial Chemotherapy, vol. 37 Suppl C, 1996, pp. 37-44.
Foulds G, Luke DR, Teng R, et al. The absence of an effect of food on the bioavailability of azithromycin administered as tablets, sachet or suspension. J Antimicrob Chemother. 1996;37 Suppl C:37-44.
Foulds, G., Luke, D. R., Teng, R., Willavize, S. A., Friedman, H., & Curatolo, W. J. (1996). The absence of an effect of food on the bioavailability of azithromycin administered as tablets, sachet or suspension. The Journal of Antimicrobial Chemotherapy, 37 Suppl C, 37-44.
Foulds G, et al. The Absence of an Effect of Food On the Bioavailability of Azithromycin Administered as Tablets, Sachet or Suspension. J Antimicrob Chemother. 1996;37 Suppl C:37-44. PubMed PMID: 8818844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The absence of an effect of food on the bioavailability of azithromycin administered as tablets, sachet or suspension. AU - Foulds,G, AU - Luke,D R, AU - Teng,R, AU - Willavize,S A, AU - Friedman,H, AU - Curatolo,W J, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 37 EP - 44 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 37 Suppl C N2 - Present product labelling indicates that azithromycin capsules should not be taken with food. However, three recent studies demonstrated that food does not significantly decrease the bioavilabilities of three new formulations of azithromycin (250 mg tablets, 1000 mg sachet, 500 mg paediatric suspension). With a 500 mg dosage, the mean relative bioavailability of azithromycin following ingestion of a standard high-fat breakfast was 96% when administered as two 250 mg tablets and 113% when administered as a suspension. The mean relative bioavailability of a 1000 mg sachet was 112%. The absolute bioavailability of the sachet formulation, relative to a 1 h iv infusion of 1000 mg, was 44%. Thus, azithromycin tablets, suspension and sachet may be given without regard to meals, further enhancing the convenience of once-daily, short-duration dosing regimens. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/8818844/full_citation L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/37.suppl_c.37 DB - PRIME DP - Unbound Medicine ER -