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Neurologic findings of vitamin B12 deficiency: presentation of 7 cases.
Turk J Pediatr. 1996 Jan-Mar; 38(1):67-72.TJ

Abstract

In this report, seven children, four males and three females, between the ages of five and 16 years with megaloblastic anemia and neuropsychiatric disorders are presented. Macrocytosis was identified in peripheral blood smears in all seven patients. Serum B12 levels were markedly reduced in four and were at the lower limit of normal in three patients. The Schilling test showed that B12 deficiency was due to specific cobalamin malabsorption in five and to inadequate dietary intake in two patients. Both neurological and hematological findings returned to normal after B12 replacement. This study shows that B12 deficiency should be considered in the differential diagnosis of neuropsychiatric disorders in children, including those with nonvegetarian habits, and that such patients should undergo a thorough hematological evaluation.

Authors+Show Affiliations

Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8819623

Citation

Kalayci, O, et al. "Neurologic Findings of Vitamin B12 Deficiency: Presentation of 7 Cases." The Turkish Journal of Pediatrics, vol. 38, no. 1, 1996, pp. 67-72.
Kalayci O, Cetin M, Kirel B, et al. Neurologic findings of vitamin B12 deficiency: presentation of 7 cases. Turk J Pediatr. 1996;38(1):67-72.
Kalayci, O., Cetin, M., Kirel, B., Ozdirim, E., Yetgin, S., Aysun, S., & Gurgey, A. (1996). Neurologic findings of vitamin B12 deficiency: presentation of 7 cases. The Turkish Journal of Pediatrics, 38(1), 67-72.
Kalayci O, et al. Neurologic Findings of Vitamin B12 Deficiency: Presentation of 7 Cases. Turk J Pediatr. 1996 Jan-Mar;38(1):67-72. PubMed PMID: 8819623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurologic findings of vitamin B12 deficiency: presentation of 7 cases. AU - Kalayci,O, AU - Cetin,M, AU - Kirel,B, AU - Ozdirim,E, AU - Yetgin,S, AU - Aysun,S, AU - Gurgey,A, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 67 EP - 72 JF - The Turkish journal of pediatrics JO - Turk J Pediatr VL - 38 IS - 1 N2 - In this report, seven children, four males and three females, between the ages of five and 16 years with megaloblastic anemia and neuropsychiatric disorders are presented. Macrocytosis was identified in peripheral blood smears in all seven patients. Serum B12 levels were markedly reduced in four and were at the lower limit of normal in three patients. The Schilling test showed that B12 deficiency was due to specific cobalamin malabsorption in five and to inadequate dietary intake in two patients. Both neurological and hematological findings returned to normal after B12 replacement. This study shows that B12 deficiency should be considered in the differential diagnosis of neuropsychiatric disorders in children, including those with nonvegetarian habits, and that such patients should undergo a thorough hematological evaluation. SN - 0041-4301 UR - https://www.unboundmedicine.com/medline/citation/8819623/Neurologic_findings_of_vitamin_B12_deficiency:_presentation_of_7_cases_ DB - PRIME DP - Unbound Medicine ER -