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A study of HLA-A, B, C, and DR specificities in pigeon breeder's disease.
Am Rev Respir Dis. 1979 May; 119(5):755-9.AR

Abstract

The frequencies of HLA-A, -B, and -C antigens were determined among 51 symptomatic pigeon breeders, 102 asymptomatic pigeon breeders, and 100 normal blood donors. The HLA-DR specificities were also studied in 32 symptomatic and 29 asymptomatic pigeon breeders. All subjects were white. Symptomatic subjects were defined by the development of respiratory symptoms or decreased pulmonary function after aerosol challenge with pigeon serum. Asymptomatic subjects were comparably exposed to pigeons but had no pulmonary signs or symptoms after aerosol challenge. No significant association was found between any of the tested HLA specificities and pigeon breeders. This lack of association and the observed paucity of multiplex families indicate that HLA complex genetic factors tested in this study do not favor the development of pigeon breeder's disease in exposed persons.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

88199

Citation

Rodey, G E., et al. "A Study of HLA-A, B, C, and DR Specificities in Pigeon Breeder's Disease." The American Review of Respiratory Disease, vol. 119, no. 5, 1979, pp. 755-9.
Rodey GE, Fink J, Koethe S, et al. A study of HLA-A, B, C, and DR specificities in pigeon breeder's disease. Am Rev Respir Dis. 1979;119(5):755-9.
Rodey, G. E., Fink, J., Koethe, S., Schlueter, D., Witkowski, J., Bettonville, P., Rimm, A., & Moore, V. (1979). A study of HLA-A, B, C, and DR specificities in pigeon breeder's disease. The American Review of Respiratory Disease, 119(5), 755-9.
Rodey GE, et al. A Study of HLA-A, B, C, and DR Specificities in Pigeon Breeder's Disease. Am Rev Respir Dis. 1979;119(5):755-9. PubMed PMID: 88199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of HLA-A, B, C, and DR specificities in pigeon breeder's disease. AU - Rodey,G E, AU - Fink,J, AU - Koethe,S, AU - Schlueter,D, AU - Witkowski,J, AU - Bettonville,P, AU - Rimm,A, AU - Moore,V, PY - 1979/5/1/pubmed PY - 1979/5/1/medline PY - 1979/5/1/entrez SP - 755 EP - 9 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 119 IS - 5 N2 - The frequencies of HLA-A, -B, and -C antigens were determined among 51 symptomatic pigeon breeders, 102 asymptomatic pigeon breeders, and 100 normal blood donors. The HLA-DR specificities were also studied in 32 symptomatic and 29 asymptomatic pigeon breeders. All subjects were white. Symptomatic subjects were defined by the development of respiratory symptoms or decreased pulmonary function after aerosol challenge with pigeon serum. Asymptomatic subjects were comparably exposed to pigeons but had no pulmonary signs or symptoms after aerosol challenge. No significant association was found between any of the tested HLA specificities and pigeon breeders. This lack of association and the observed paucity of multiplex families indicate that HLA complex genetic factors tested in this study do not favor the development of pigeon breeder's disease in exposed persons. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/88199/A_study_of_HLA_A_B_C_and_DR_specificities_in_pigeon_breeder's_disease_ L2 - https://www.atsjournals.org/doi/10.1164/arrd.1979.119.5.755?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -