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Influence of hypotension on cochlear blood flow in polycythemic condition.
Acta Otolaryngol. 1996 Jan; 116(1):33-8.AO

Abstract

We examined the influence of hypotension by infusion of acebutolol hydrochloride (AH), a cardioselective beta-receptor antagonist, on cochlear blood flow in guinea pigs with various hematocrit values. AH infusion lowered the mean blood pressure to almost the same degree in all animals, regardless of the hematocrit level. The degree of the concomitant decrease of CBF varied with the hematocrit, being greater in animals with a higher hematocrit. In those with the highest hematocrit CBF did not return to the initial level. From these values we calculated the O2 transport capacity after AH infusion and found it to be lower than in animals without AH infusion. The difference was greater at higher hematocrits. These findings suggest that the microcirculation of the inner ear is responsive to transient decreases of perfusion pressure at high hematocrits.

Authors+Show Affiliations

Department of Otolaryngology, Saiseikai Nakatsu Hospital, Osaka, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8820347

Citation

Ohinata, Y, et al. "Influence of Hypotension On Cochlear Blood Flow in Polycythemic Condition." Acta Oto-laryngologica, vol. 116, no. 1, 1996, pp. 33-8.
Ohinata Y, Makimoto K, Takahashi H. Influence of hypotension on cochlear blood flow in polycythemic condition. Acta Otolaryngol. 1996;116(1):33-8.
Ohinata, Y., Makimoto, K., & Takahashi, H. (1996). Influence of hypotension on cochlear blood flow in polycythemic condition. Acta Oto-laryngologica, 116(1), 33-8.
Ohinata Y, Makimoto K, Takahashi H. Influence of Hypotension On Cochlear Blood Flow in Polycythemic Condition. Acta Otolaryngol. 1996;116(1):33-8. PubMed PMID: 8820347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of hypotension on cochlear blood flow in polycythemic condition. AU - Ohinata,Y, AU - Makimoto,K, AU - Takahashi,H, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 33 EP - 8 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 116 IS - 1 N2 - We examined the influence of hypotension by infusion of acebutolol hydrochloride (AH), a cardioselective beta-receptor antagonist, on cochlear blood flow in guinea pigs with various hematocrit values. AH infusion lowered the mean blood pressure to almost the same degree in all animals, regardless of the hematocrit level. The degree of the concomitant decrease of CBF varied with the hematocrit, being greater in animals with a higher hematocrit. In those with the highest hematocrit CBF did not return to the initial level. From these values we calculated the O2 transport capacity after AH infusion and found it to be lower than in animals without AH infusion. The difference was greater at higher hematocrits. These findings suggest that the microcirculation of the inner ear is responsive to transient decreases of perfusion pressure at high hematocrits. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/8820347/Influence_of_hypotension_on_cochlear_blood_flow_in_polycythemic_condition_ L2 - http://www.tandfonline.com/doi/full/10.3109/00016489609137709 DB - PRIME DP - Unbound Medicine ER -