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Evidence for apolipoprotein E epsilon 4 association in early-onset Alzheimer's patients with late-onset relatives.
Am J Med Genet. 1995 Dec 18; 60(6):550-3.AJ

Abstract

Recently several reports have extended the apolipoprotein E (APOE) epsilon 4 association found in late-onset Alzheimer's disease (LOAD) patients to early-onset (EO) AD patients. We have studied this question in a large population of 119 EOAD patients (onset < or = 60 years) in which family history was carefully assessed and in 109 controls. We show that the APOE epsilon 4 allele frequency is increased only in the subset of patients who belong to families where LOAD secondary cases are present. Our sampling scheme permits us to demonstrate that for an individual, bearing at least one epsilon 4 allele increases both the risk of AD before age 60 and the probability of belonging to a family with late-onset affected subjects. Our results suggest that a subset of EOAD cases shares a common determinism with LOAD cases.

Authors+Show Affiliations

Unité 422 INSERM, Lille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8825894

Citation

Pérez-Tur, J, et al. "Evidence for Apolipoprotein E Epsilon 4 Association in Early-onset Alzheimer's Patients With Late-onset Relatives." American Journal of Medical Genetics, vol. 60, no. 6, 1995, pp. 550-3.
Pérez-Tur J, Campion D, Martinez M, et al. Evidence for apolipoprotein E epsilon 4 association in early-onset Alzheimer's patients with late-onset relatives. Am J Med Genet. 1995;60(6):550-3.
Pérez-Tur, J., Campion, D., Martinez, M., Brice, A., Tardieu, S., Hannequin, D., Agid, Y., Delacourte, A., Clerget-Darpoux, F., & Chartier-Harlin, M. C. (1995). Evidence for apolipoprotein E epsilon 4 association in early-onset Alzheimer's patients with late-onset relatives. American Journal of Medical Genetics, 60(6), 550-3.
Pérez-Tur J, et al. Evidence for Apolipoprotein E Epsilon 4 Association in Early-onset Alzheimer's Patients With Late-onset Relatives. Am J Med Genet. 1995 Dec 18;60(6):550-3. PubMed PMID: 8825894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for apolipoprotein E epsilon 4 association in early-onset Alzheimer's patients with late-onset relatives. AU - Pérez-Tur,J, AU - Campion,D, AU - Martinez,M, AU - Brice,A, AU - Tardieu,S, AU - Hannequin,D, AU - Agid,Y, AU - Delacourte,A, AU - Clerget-Darpoux,F, AU - Chartier-Harlin,M C, PY - 1995/12/18/pubmed PY - 1995/12/18/medline PY - 1995/12/18/entrez SP - 550 EP - 3 JF - American journal of medical genetics JO - Am. J. Med. Genet. VL - 60 IS - 6 N2 - Recently several reports have extended the apolipoprotein E (APOE) epsilon 4 association found in late-onset Alzheimer's disease (LOAD) patients to early-onset (EO) AD patients. We have studied this question in a large population of 119 EOAD patients (onset < or = 60 years) in which family history was carefully assessed and in 109 controls. We show that the APOE epsilon 4 allele frequency is increased only in the subset of patients who belong to families where LOAD secondary cases are present. Our sampling scheme permits us to demonstrate that for an individual, bearing at least one epsilon 4 allele increases both the risk of AD before age 60 and the probability of belonging to a family with late-onset affected subjects. Our results suggest that a subset of EOAD cases shares a common determinism with LOAD cases. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/8825894/Evidence_for_apolipoprotein_E_epsilon_4_association_in_early_onset_Alzheimer's_patients_with_late_onset_relatives_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0148-7299&amp;date=1995&amp;volume=60&amp;issue=6&amp;spage=550 DB - PRIME DP - Unbound Medicine ER -