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Randomized clinical trial of chlorhexidine versus placebo for prevention of oral mucositis in patients receiving chemotherapy.
Oncol Nurs Forum 1996; 23(6):921-7ON

Abstract

PURPOSE/OBJECTIVES

To test the effectiveness of a nurse-initiated systematic oral hygiene teaching program-PRO-SELF: Mouth Aware (PSMA)-in conjunction with two mouthwashes (0.12% chlorhexidine or sterile water) in preventing chemotherapy-induced oral mucositis.

DESIGN

Randomized, double-blind, placebo-controlled, clinical trial.

SETTINGS

23 outpatient clinics and office practices in California.

SAMPLE

222 patients who were starting a cycle of mucositis-inducing chemotherapy.

METHOD

Participants were followed over three chemotherapy cycles. All patients were provided the PSMA program. Random assignment to a mouthwash occurred prior to the development of oral mucositis. Researchers used the Oral Assessment Guide to assess the patients oral cavities monthly (with the patients cycles of chemotherapy) and when patients reported any oral changes between cycles.

MAIN RESEARCH VARIABLES

Type of mouthwash, incidence, days to onset, and severity of chemotherapy-induced oral mucositis.

FINDINGS

No significant differences existed between the two mouthwashes in regard to incidence, days to onset, and severity of mucositis.

CONCLUSIONS

Because chlorhexidine (S20 per pint) was no more effective than water, a substantial cost savings can be realized by rinsing with water. Interestingly, the PSMA program appeared to reduce the incidence of mucositis from on a prior estimate of 44% to less than 26%.

IMPLICATIONS FOR NURSING PRACTICE

A nursing prescription of a systematic oral hygiene program using water as a mouth rinse is cost efficient and may be effective in preventing oral mucositis.

Authors+Show Affiliations

University of California, San Francisco School of Nursing, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8829162

Citation

Dodd, M J., et al. "Randomized Clinical Trial of Chlorhexidine Versus Placebo for Prevention of Oral Mucositis in Patients Receiving Chemotherapy." Oncology Nursing Forum, vol. 23, no. 6, 1996, pp. 921-7.
Dodd MJ, Larson PJ, Dibble SL, et al. Randomized clinical trial of chlorhexidine versus placebo for prevention of oral mucositis in patients receiving chemotherapy. Oncol Nurs Forum. 1996;23(6):921-7.
Dodd, M. J., Larson, P. J., Dibble, S. L., Miaskowski, C., Greenspan, D., MacPhail, L., ... Shiba, G. (1996). Randomized clinical trial of chlorhexidine versus placebo for prevention of oral mucositis in patients receiving chemotherapy. Oncology Nursing Forum, 23(6), pp. 921-7.
Dodd MJ, et al. Randomized Clinical Trial of Chlorhexidine Versus Placebo for Prevention of Oral Mucositis in Patients Receiving Chemotherapy. Oncol Nurs Forum. 1996;23(6):921-7. PubMed PMID: 8829162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized clinical trial of chlorhexidine versus placebo for prevention of oral mucositis in patients receiving chemotherapy. AU - Dodd,M J, AU - Larson,P J, AU - Dibble,S L, AU - Miaskowski,C, AU - Greenspan,D, AU - MacPhail,L, AU - Hauck,W W, AU - Paul,S M, AU - Ignoffo,R, AU - Shiba,G, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 921 EP - 7 JF - Oncology nursing forum JO - Oncol Nurs Forum VL - 23 IS - 6 N2 - PURPOSE/OBJECTIVES: To test the effectiveness of a nurse-initiated systematic oral hygiene teaching program-PRO-SELF: Mouth Aware (PSMA)-in conjunction with two mouthwashes (0.12% chlorhexidine or sterile water) in preventing chemotherapy-induced oral mucositis. DESIGN: Randomized, double-blind, placebo-controlled, clinical trial. SETTINGS: 23 outpatient clinics and office practices in California. SAMPLE: 222 patients who were starting a cycle of mucositis-inducing chemotherapy. METHOD: Participants were followed over three chemotherapy cycles. All patients were provided the PSMA program. Random assignment to a mouthwash occurred prior to the development of oral mucositis. Researchers used the Oral Assessment Guide to assess the patients oral cavities monthly (with the patients cycles of chemotherapy) and when patients reported any oral changes between cycles. MAIN RESEARCH VARIABLES: Type of mouthwash, incidence, days to onset, and severity of chemotherapy-induced oral mucositis. FINDINGS: No significant differences existed between the two mouthwashes in regard to incidence, days to onset, and severity of mucositis. CONCLUSIONS: Because chlorhexidine (S20 per pint) was no more effective than water, a substantial cost savings can be realized by rinsing with water. Interestingly, the PSMA program appeared to reduce the incidence of mucositis from on a prior estimate of 44% to less than 26%. IMPLICATIONS FOR NURSING PRACTICE: A nursing prescription of a systematic oral hygiene program using water as a mouth rinse is cost efficient and may be effective in preventing oral mucositis. SN - 0190-535X UR - https://www.unboundmedicine.com/medline/citation/8829162/Randomized_clinical_trial_of_chlorhexidine_versus_placebo_for_prevention_of_oral_mucositis_in_patients_receiving_chemotherapy_ DB - PRIME DP - Unbound Medicine ER -