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[Limits of PINI (prognostic nutritional anf inflammatory index) in the evaluation of nutritional status in children].

Abstract

The prognosis inflammatory and nutritional index (PINI) is a score based on albumin, glycoprotein acid and C-reactive protein levels. PINI was developed to evaluate nutritional and inflammatory status of patients presenting inflammatory syndromes with or without denutrition. In the present study conducted over a period of 6 days in the Pediatric Department of Bambri Hospital in the Central African Republic, we evaluated the usefulness of PINI for follow-up of 25 undernourished Central African children presenting marasmus (n = 15) or kwashiorkor (n = 10) associated with a laboratory documented inflammatory process. All children received nutritional support. We assessed the influence of inflammatory and nutritional factors on PINI values. Data measured in blood samples taken from 16 patients who also presented documented inflammatory manifestations but were not undernourished. A parallel decrease in C-reactive protein and PINI was observed from D0 to D6 and an increase in albumin and prealbumin from D3. There was a positive correlation between C reactive protein values and PINI on D0, D3 and D6. There was no significance difference between PINI and C reactive protein levels in the two study groups. In contrast, a significant difference was observed between albumin and prealbumin. These findings indicate that PINI is of little value for evaluation of inflammatory processes associated with malnutrition. The two main drawbacks of PINI are first that it is more sensitive to the inflammatory than nutritional factors and second that the physical and pharmakinetic parameters used for its calculation are too different.

Authors+Show Affiliations

,

Service de Biochemie, l'Hôpital d'Instruction des Armées Laveran, Marseille, France

,

Source

MeSH

C-Reactive Protein
Case-Control Studies
Central African Republic
Child Nutrition Disorders
Child, Preschool
Female
Follow-Up Studies
Glycoproteins
Humans
Infant
Inflammation
Kwashiorkor
Male
Nutrition Assessment
Prealbumin
Protein-Energy Malnutrition
Reproducibility of Results
Sensitivity and Specificity
Serum Albumin

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

8830217

Citation

Rault, J P., et al. "[Limits of PINI (prognostic Nutritional Anf Inflammatory Index) in the Evaluation of Nutritional Status in Children]." Medecine Tropicale : Revue Du Corps De Sante Colonial, vol. 55, no. 4, 1995, pp. 343-6.
Rault JP, Adam F, Simon F. [Limits of PINI (prognostic nutritional anf inflammatory index) in the evaluation of nutritional status in children]. Med Trop (Mars). 1995;55(4):343-6.
Rault, J. P., Adam, F., & Simon, F. (1995). [Limits of PINI (prognostic nutritional anf inflammatory index) in the evaluation of nutritional status in children]. Medecine Tropicale : Revue Du Corps De Sante Colonial, 55(4), pp. 343-6.
Rault JP, Adam F, Simon F. [Limits of PINI (prognostic Nutritional Anf Inflammatory Index) in the Evaluation of Nutritional Status in Children]. Med Trop (Mars). 1995;55(4):343-6. PubMed PMID: 8830217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Limits of PINI (prognostic nutritional anf inflammatory index) in the evaluation of nutritional status in children]. AU - Rault,J P, AU - Adam,F, AU - Simon,F, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 343 EP - 6 JF - Medecine tropicale : revue du Corps de sante colonial JO - Med Trop (Mars) VL - 55 IS - 4 N2 - The prognosis inflammatory and nutritional index (PINI) is a score based on albumin, glycoprotein acid and C-reactive protein levels. PINI was developed to evaluate nutritional and inflammatory status of patients presenting inflammatory syndromes with or without denutrition. In the present study conducted over a period of 6 days in the Pediatric Department of Bambri Hospital in the Central African Republic, we evaluated the usefulness of PINI for follow-up of 25 undernourished Central African children presenting marasmus (n = 15) or kwashiorkor (n = 10) associated with a laboratory documented inflammatory process. All children received nutritional support. We assessed the influence of inflammatory and nutritional factors on PINI values. Data measured in blood samples taken from 16 patients who also presented documented inflammatory manifestations but were not undernourished. A parallel decrease in C-reactive protein and PINI was observed from D0 to D6 and an increase in albumin and prealbumin from D3. There was a positive correlation between C reactive protein values and PINI on D0, D3 and D6. There was no significance difference between PINI and C reactive protein levels in the two study groups. In contrast, a significant difference was observed between albumin and prealbumin. These findings indicate that PINI is of little value for evaluation of inflammatory processes associated with malnutrition. The two main drawbacks of PINI are first that it is more sensitive to the inflammatory than nutritional factors and second that the physical and pharmakinetic parameters used for its calculation are too different. SN - 0025-682X UR - https://www.unboundmedicine.com/medline/citation/8830217/[Limits_of_PINI__prognostic_nutritional_anf_inflammatory_index__in_the_evaluation_of_nutritional_status_in_children]_ L2 - https://medlineplus.gov/childnutrition.html DB - PRIME DP - Unbound Medicine ER -