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Donor leukocyte transfusions and discontinuation of immunosuppressants to achieve an initial remission after allogeneic bone marrow transplantation in a patient with primary refractory acute leukemia.
Bone Marrow Transplant. 1996 Jul; 18(1):257-9.BM

Abstract

We present a female patient who received an allogeneic bone marrow transplantation for primary refractory Philadelphia-positive acute biphenotypic leukemia. Since leukemic blasts were persistently present in peripheral blood and bone marrow, in spite of the evidence for engraftment of male donor hematopoiesis, we performed donor leukocyte transfusions and discontinued immunosuppression. An initial complete remission was obtained 15 weeks after allogeneic bone marrow transplantation, and lasted for 24 weeks. We concluded that the prominent mechanism for the eradication of the refractory leukemic clone in the patient was the graft-versus-leukemia effect.

Authors+Show Affiliations

Department of Internal Medicine, Yamaguchi Rosai Hospital, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8832032

Citation

Azuno, Y, et al. "Donor Leukocyte Transfusions and Discontinuation of Immunosuppressants to Achieve an Initial Remission After Allogeneic Bone Marrow Transplantation in a Patient With Primary Refractory Acute Leukemia." Bone Marrow Transplantation, vol. 18, no. 1, 1996, pp. 257-9.
Azuno Y, Kaneko T, Nishimura M, et al. Donor leukocyte transfusions and discontinuation of immunosuppressants to achieve an initial remission after allogeneic bone marrow transplantation in a patient with primary refractory acute leukemia. Bone Marrow Transplant. 1996;18(1):257-9.
Azuno, Y., Kaneko, T., Nishimura, M., Okuya, S., Nakai, K., Nomiyama, J., Mori, K., Okafuji, K., Okubo, M., Matsutani, A., Kamei, S., Zaitsu, Y., Takeuchi, Y., Oka, Y., & Kaku, K. (1996). Donor leukocyte transfusions and discontinuation of immunosuppressants to achieve an initial remission after allogeneic bone marrow transplantation in a patient with primary refractory acute leukemia. Bone Marrow Transplantation, 18(1), 257-9.
Azuno Y, et al. Donor Leukocyte Transfusions and Discontinuation of Immunosuppressants to Achieve an Initial Remission After Allogeneic Bone Marrow Transplantation in a Patient With Primary Refractory Acute Leukemia. Bone Marrow Transplant. 1996;18(1):257-9. PubMed PMID: 8832032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Donor leukocyte transfusions and discontinuation of immunosuppressants to achieve an initial remission after allogeneic bone marrow transplantation in a patient with primary refractory acute leukemia. AU - Azuno,Y, AU - Kaneko,T, AU - Nishimura,M, AU - Okuya,S, AU - Nakai,K, AU - Nomiyama,J, AU - Mori,K, AU - Okafuji,K, AU - Okubo,M, AU - Matsutani,A, AU - Kamei,S, AU - Zaitsu,Y, AU - Takeuchi,Y, AU - Oka,Y, AU - Kaku,K, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 257 EP - 9 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 18 IS - 1 N2 - We present a female patient who received an allogeneic bone marrow transplantation for primary refractory Philadelphia-positive acute biphenotypic leukemia. Since leukemic blasts were persistently present in peripheral blood and bone marrow, in spite of the evidence for engraftment of male donor hematopoiesis, we performed donor leukocyte transfusions and discontinued immunosuppression. An initial complete remission was obtained 15 weeks after allogeneic bone marrow transplantation, and lasted for 24 weeks. We concluded that the prominent mechanism for the eradication of the refractory leukemic clone in the patient was the graft-versus-leukemia effect. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/8832032/Donor_leukocyte_transfusions_and_discontinuation_of_immunosuppressants_to_achieve_an_initial_remission_after_allogeneic_bone_marrow_transplantation_in_a_patient_with_primary_refractory_acute_leukemia_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -