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Mechanical validation of a tomographic (pQCT) index for noninvasive estimation of rat femur bending strength.
Bone. 1996 Feb; 18(2):97-102.BONE

Abstract

Cross-sectional moment of inertia (CSMI) and volumetric cortical bone mineral density (vCtBMD) were assessed by peripheral quantitative computed tomography (pQCT) at femur midshafts from 103 Wistar female rats receiving 0 (n = 12) or 15-1000 mu g/kg/day sc of dexamethasone (n = 46) from 5 to 9 weeks of age, or 0 or 80 mg/kg 3/wk of AI(OH)(3) IP (n = 23,22) from 4 to 10 months of age. A bone strength index (BSI), calculated as the product CSMI x vCtBMD, was found to closely correlate (r = 0.94, R(2) = 0.89, p < 0.001) with the actual, mechanically tested bending breaking force of all bones. Correlation and determination coefficients obtained were higher than those usually reported employing different long-bone strength predictive formulae. The curve approached the origin and was linear throughout the wide range of CSMI, vCtBMD and BSI achieved because of age- and treatment-induced differences, showing a very low standard error of the estimate. Instead, different curve slopes and/or intercepts were found in separate analysis between data from each of the experiments when breaking force was correlated with CSMI or vCtBMD alone, or with the DEXA-assessed BMD of the mechanically assayed bone portion. Results suggest that noninvasive assessment of the BSI by means of pQCT technology provides an original tool for a precise and accurate estimation of long-bone bending strength that can be advantageously applied in crosssectional as well as longitudinal, in vivo studies employing animal models.

Authors+Show Affiliations

Centro de Estudios de Metabolismo Fosfocalcico (CEMFoC), Universidad Nacional de Rosario, Argentina.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8833202

Citation

Ferretti, J L., et al. "Mechanical Validation of a Tomographic (pQCT) Index for Noninvasive Estimation of Rat Femur Bending Strength." Bone, vol. 18, no. 2, 1996, pp. 97-102.
Ferretti JL, Capozza RF, Zanchetta JR. Mechanical validation of a tomographic (pQCT) index for noninvasive estimation of rat femur bending strength. Bone. 1996;18(2):97-102.
Ferretti, J. L., Capozza, R. F., & Zanchetta, J. R. (1996). Mechanical validation of a tomographic (pQCT) index for noninvasive estimation of rat femur bending strength. Bone, 18(2), 97-102.
Ferretti JL, Capozza RF, Zanchetta JR. Mechanical Validation of a Tomographic (pQCT) Index for Noninvasive Estimation of Rat Femur Bending Strength. Bone. 1996;18(2):97-102. PubMed PMID: 8833202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanical validation of a tomographic (pQCT) index for noninvasive estimation of rat femur bending strength. AU - Ferretti,J L, AU - Capozza,R F, AU - Zanchetta,J R, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez SP - 97 EP - 102 JF - Bone JO - Bone VL - 18 IS - 2 N2 - Cross-sectional moment of inertia (CSMI) and volumetric cortical bone mineral density (vCtBMD) were assessed by peripheral quantitative computed tomography (pQCT) at femur midshafts from 103 Wistar female rats receiving 0 (n = 12) or 15-1000 mu g/kg/day sc of dexamethasone (n = 46) from 5 to 9 weeks of age, or 0 or 80 mg/kg 3/wk of AI(OH)(3) IP (n = 23,22) from 4 to 10 months of age. A bone strength index (BSI), calculated as the product CSMI x vCtBMD, was found to closely correlate (r = 0.94, R(2) = 0.89, p < 0.001) with the actual, mechanically tested bending breaking force of all bones. Correlation and determination coefficients obtained were higher than those usually reported employing different long-bone strength predictive formulae. The curve approached the origin and was linear throughout the wide range of CSMI, vCtBMD and BSI achieved because of age- and treatment-induced differences, showing a very low standard error of the estimate. Instead, different curve slopes and/or intercepts were found in separate analysis between data from each of the experiments when breaking force was correlated with CSMI or vCtBMD alone, or with the DEXA-assessed BMD of the mechanically assayed bone portion. Results suggest that noninvasive assessment of the BSI by means of pQCT technology provides an original tool for a precise and accurate estimation of long-bone bending strength that can be advantageously applied in crosssectional as well as longitudinal, in vivo studies employing animal models. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/8833202/Mechanical_validation_of_a_tomographic__pQCT__index_for_noninvasive_estimation_of_rat_femur_bending_strength_ L2 - https://linkinghub.elsevier.com/retrieve/pii/8756-3282(95)00438-6 DB - PRIME DP - Unbound Medicine ER -