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Tumor necrosis factor receptor p55 mediates induction of HIV type 1 expression in chronically infected U1 cells.
AIDS Res Hum Retroviruses. 1996 Feb 10; 12(3):199-204.AR

Abstract

Tumor necrosis factor alpha (TNF-alpha) is a potent inducer of human immunodeficiency virus type 1 (HIV-1) expression in chronically infected cells. The aim of this study was to investigate the role played by the two known TNF-alpha receptors, TNFR-p55 and TNFR-p75, in the activation of HIV-1 expression. As a model system the latently infected human promonocytic cell line U1 was stimulated with wild-type TNF-alpha, with TNF-alpha muteins that specifically bind to one or the other receptor or with receptor-specific monoclonal antibodies. Induction of HIV-1 expression, measured by p24 core antigen capture enzyme-linked immunosorbent assay (ELISA), was found to be exclusively triggered by TNFR-p55 stimulation. However, our results also showed that the addition of TNFR-p75-specific ligands negatively modulated the HIV-1 expression induced via TNFR-p55.

Authors+Show Affiliations

Pharmaceutical Research Gene Technologies, F. Hoffmann-La Roche Ltd., Basel, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8835197

Citation

Edfjäll, C, et al. "Tumor Necrosis Factor Receptor P55 Mediates Induction of HIV Type 1 Expression in Chronically Infected U1 Cells." AIDS Research and Human Retroviruses, vol. 12, no. 3, 1996, pp. 199-204.
Edfjäll C, Jacobsen H, Lötscher H, et al. Tumor necrosis factor receptor p55 mediates induction of HIV type 1 expression in chronically infected U1 cells. AIDS Res Hum Retroviruses. 1996;12(3):199-204.
Edfjäll, C., Jacobsen, H., Lötscher, H., & Mous, J. (1996). Tumor necrosis factor receptor p55 mediates induction of HIV type 1 expression in chronically infected U1 cells. AIDS Research and Human Retroviruses, 12(3), 199-204.
Edfjäll C, et al. Tumor Necrosis Factor Receptor P55 Mediates Induction of HIV Type 1 Expression in Chronically Infected U1 Cells. AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):199-204. PubMed PMID: 8835197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumor necrosis factor receptor p55 mediates induction of HIV type 1 expression in chronically infected U1 cells. AU - Edfjäll,C, AU - Jacobsen,H, AU - Lötscher,H, AU - Mous,J, PY - 1996/2/10/pubmed PY - 1996/2/10/medline PY - 1996/2/10/entrez SP - 199 EP - 204 JF - AIDS research and human retroviruses JO - AIDS Res Hum Retroviruses VL - 12 IS - 3 N2 - Tumor necrosis factor alpha (TNF-alpha) is a potent inducer of human immunodeficiency virus type 1 (HIV-1) expression in chronically infected cells. The aim of this study was to investigate the role played by the two known TNF-alpha receptors, TNFR-p55 and TNFR-p75, in the activation of HIV-1 expression. As a model system the latently infected human promonocytic cell line U1 was stimulated with wild-type TNF-alpha, with TNF-alpha muteins that specifically bind to one or the other receptor or with receptor-specific monoclonal antibodies. Induction of HIV-1 expression, measured by p24 core antigen capture enzyme-linked immunosorbent assay (ELISA), was found to be exclusively triggered by TNFR-p55 stimulation. However, our results also showed that the addition of TNFR-p75-specific ligands negatively modulated the HIV-1 expression induced via TNFR-p55. SN - 0889-2229 UR - https://www.unboundmedicine.com/medline/citation/8835197/Tumor_necrosis_factor_receptor_p55_mediates_induction_of_HIV_type_1_expression_in_chronically_infected_U1_cells_ L2 - https://www.liebertpub.com/doi/10.1089/aid.1996.12.199?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -