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Effects of clofibrate on lipids and fatty acids of mouse liver.
Lipids. 1996 Feb; 31(2):179-85.L

Abstract

Clofibrate administration significantly altered the amount and fatty acid composition of lipids in mouse liver. The net content of phospholipids (PL) increased and that of triacylglycerols (TG) decreased concomitantly with liver enlargement in mice treated for two weeks with this drug (0.5% w/w in the food). The highest increase among PL was in phosphatidylcholine; other components either showed lower increases or, as in the case of sphingomyelin and the plasmalogens, decreased. In all lipid classes the treatment resulted in altered ratios between major saturates, between saturates and monoenes, and between major polyenes. Among these, 20:3n-6 and 22:5n-3 increased several-fold, and the 20:3n-6/20:4n-6 and 22:5n-3/22:6n-3 ratios increased due to a more active formation of the precursors than of the corresponding products. This change affected all glycerolipid classes. Liver sphingomyelin showed a relative enrichment in monoenoic fatty acids like 22:1 and 24:1, caused by a net decrease in the amount of saturates, particularly 22:0 and 24:0. The stimulated membrane proliferation imposed by clofibrate must increase phospholipid synthesis and, hence, the need for fatty acids. The results suggest that these demands are met mostly by TG acyl groups, either directly or after oxidation/desaturation processes. This was apparently the case for the polyenoic fatty acids of the n-6 and n-3 series. The longer chain (C22 and C24) components decreased, suggesting that their oxidation was stimulated to provide part of the required (C20 and C22) polyenes.

Authors+Show Affiliations

Instituto de Investigaciones Bioquímicas de Bahía Blanca, Universidad Nacional del Sur, Argentina.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8835406

Citation

Pennacchiotti, G L., et al. "Effects of Clofibrate On Lipids and Fatty Acids of Mouse Liver." Lipids, vol. 31, no. 2, 1996, pp. 179-85.
Pennacchiotti GL, Rotstein NP, Aveldaño MI. Effects of clofibrate on lipids and fatty acids of mouse liver. Lipids. 1996;31(2):179-85.
Pennacchiotti, G. L., Rotstein, N. P., & Aveldaño, M. I. (1996). Effects of clofibrate on lipids and fatty acids of mouse liver. Lipids, 31(2), 179-85.
Pennacchiotti GL, Rotstein NP, Aveldaño MI. Effects of Clofibrate On Lipids and Fatty Acids of Mouse Liver. Lipids. 1996;31(2):179-85. PubMed PMID: 8835406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of clofibrate on lipids and fatty acids of mouse liver. AU - Pennacchiotti,G L, AU - Rotstein,N P, AU - Aveldaño,M I, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez SP - 179 EP - 85 JF - Lipids JO - Lipids VL - 31 IS - 2 N2 - Clofibrate administration significantly altered the amount and fatty acid composition of lipids in mouse liver. The net content of phospholipids (PL) increased and that of triacylglycerols (TG) decreased concomitantly with liver enlargement in mice treated for two weeks with this drug (0.5% w/w in the food). The highest increase among PL was in phosphatidylcholine; other components either showed lower increases or, as in the case of sphingomyelin and the plasmalogens, decreased. In all lipid classes the treatment resulted in altered ratios between major saturates, between saturates and monoenes, and between major polyenes. Among these, 20:3n-6 and 22:5n-3 increased several-fold, and the 20:3n-6/20:4n-6 and 22:5n-3/22:6n-3 ratios increased due to a more active formation of the precursors than of the corresponding products. This change affected all glycerolipid classes. Liver sphingomyelin showed a relative enrichment in monoenoic fatty acids like 22:1 and 24:1, caused by a net decrease in the amount of saturates, particularly 22:0 and 24:0. The stimulated membrane proliferation imposed by clofibrate must increase phospholipid synthesis and, hence, the need for fatty acids. The results suggest that these demands are met mostly by TG acyl groups, either directly or after oxidation/desaturation processes. This was apparently the case for the polyenoic fatty acids of the n-6 and n-3 series. The longer chain (C22 and C24) components decreased, suggesting that their oxidation was stimulated to provide part of the required (C20 and C22) polyenes. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/8835406/Effects_of_clofibrate_on_lipids_and_fatty_acids_of_mouse_liver_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=1996&volume=31&issue=2&spage=179 DB - PRIME DP - Unbound Medicine ER -