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Mild forms of dentinogenesis imperfecta in association with osteogenesis imperfecta as characterized by light and transmission electron microscopy.
J Oral Pathol Med. 1996 May; 25(5):256-64.JO

Abstract

Osteogenesis imperfecta (OI) results from various gene mutations leading to defects in type I collagen, which is the major component of both bone and dentin. Yet dentinogenesis imperfecta (DI) is found only in half of the patients with OI. Here we document patients from three families with OI and DI lacking the clinical and radiographic features of DI in permanent teeth. However, light and transmission electron microscopic studies of dentin of deciduous and permanent teeth revealed various changes in the morphology of the dentinal tubules and collagen fibers. In one family, diagnosis of DI preceded that of OI. The grade of severity of dentinal manifestations in patients with OI apparently forms a continuum from normal dentin structure to severe DI, and the marked difficulty in diagnosing mild DI may have led to underestimating its frequency. Furthermore, patients with DI should be carefully examined for the possible presence of OI.

Authors+Show Affiliations

Department of Pedodontics, University of Helsinki, FinlandNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8835824

Citation

Waltimo, J, et al. "Mild Forms of Dentinogenesis Imperfecta in Association With Osteogenesis Imperfecta as Characterized By Light and Transmission Electron Microscopy." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 25, no. 5, 1996, pp. 256-64.
Waltimo J, Ojanotko-Harri A, Lukinmaa PL. Mild forms of dentinogenesis imperfecta in association with osteogenesis imperfecta as characterized by light and transmission electron microscopy. J Oral Pathol Med. 1996;25(5):256-64.
Waltimo, J., Ojanotko-Harri, A., & Lukinmaa, P. L. (1996). Mild forms of dentinogenesis imperfecta in association with osteogenesis imperfecta as characterized by light and transmission electron microscopy. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 25(5), 256-64.
Waltimo J, Ojanotko-Harri A, Lukinmaa PL. Mild Forms of Dentinogenesis Imperfecta in Association With Osteogenesis Imperfecta as Characterized By Light and Transmission Electron Microscopy. J Oral Pathol Med. 1996;25(5):256-64. PubMed PMID: 8835824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mild forms of dentinogenesis imperfecta in association with osteogenesis imperfecta as characterized by light and transmission electron microscopy. AU - Waltimo,J, AU - Ojanotko-Harri,A, AU - Lukinmaa,P L, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 256 EP - 64 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 25 IS - 5 N2 - Osteogenesis imperfecta (OI) results from various gene mutations leading to defects in type I collagen, which is the major component of both bone and dentin. Yet dentinogenesis imperfecta (DI) is found only in half of the patients with OI. Here we document patients from three families with OI and DI lacking the clinical and radiographic features of DI in permanent teeth. However, light and transmission electron microscopic studies of dentin of deciduous and permanent teeth revealed various changes in the morphology of the dentinal tubules and collagen fibers. In one family, diagnosis of DI preceded that of OI. The grade of severity of dentinal manifestations in patients with OI apparently forms a continuum from normal dentin structure to severe DI, and the marked difficulty in diagnosing mild DI may have led to underestimating its frequency. Furthermore, patients with DI should be carefully examined for the possible presence of OI. SN - 0904-2512 UR - https://www.unboundmedicine.com/medline/citation/8835824/Mild_forms_of_dentinogenesis_imperfecta_in_association_with_osteogenesis_imperfecta_as_characterized_by_light_and_transmission_electron_microscopy_ DB - PRIME DP - Unbound Medicine ER -