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AMPA/kainate receptors mediate sympathetic chemoreceptor reflex in the rostral ventrolateral medulla.
Brain Res. 1996 Jul 08; 726(1-2):64-8.BR

Abstract

Previous studies have reported that information from carotid chemoreceptors activates sympathetic premotor neurons in the rostral ventrolateral medulla (RVLM) exclusively via N-methyl-D-aspartic acid (NMDA) receptors. In this study, we examined the possible involvement of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors in the RVLM on sympathetic chemoreceptor reflex in pentobarbitone anaesthetised, vagotomised and artificially ventilated rats. Carotid chemoreceptor stimulation with brief N2 inhalation increased splanchnic sympathetic nerve activity and arterial pressure in animals that had received an intravenous injection of the non-competitive NMDA receptor blocker, MK-801 (2 mg/kg). RVLM sympathetic premotor neurons could also be activated by brief hypoxia in the presence of MK-801. However, microinjection of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, a selective AMPA/kainate receptor antagonist, 2 mM, 100 nl) into the RVLM after intravenous MK-801 abolished the hypoxia evoked sympathoexcitatory response. These results demonstrate that AMPA/kainate receptors in the RVLM are involved in the chemoreceptor reflex pathway.

Authors+Show Affiliations

Department of Medicine, Flinders Medical Centre, Bedford Park, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8836546

Citation

Miyawaki, T, et al. "AMPA/kainate Receptors Mediate Sympathetic Chemoreceptor Reflex in the Rostral Ventrolateral Medulla." Brain Research, vol. 726, no. 1-2, 1996, pp. 64-8.
Miyawaki T, Minson J, Arnolda L, et al. AMPA/kainate receptors mediate sympathetic chemoreceptor reflex in the rostral ventrolateral medulla. Brain Res. 1996;726(1-2):64-8.
Miyawaki, T., Minson, J., Arnolda, L., Llewellyn-Smith, I., Chalmers, J., & Pilowsky, P. (1996). AMPA/kainate receptors mediate sympathetic chemoreceptor reflex in the rostral ventrolateral medulla. Brain Research, 726(1-2), 64-8.
Miyawaki T, et al. AMPA/kainate Receptors Mediate Sympathetic Chemoreceptor Reflex in the Rostral Ventrolateral Medulla. Brain Res. 1996 Jul 8;726(1-2):64-8. PubMed PMID: 8836546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - AMPA/kainate receptors mediate sympathetic chemoreceptor reflex in the rostral ventrolateral medulla. AU - Miyawaki,T, AU - Minson,J, AU - Arnolda,L, AU - Llewellyn-Smith,I, AU - Chalmers,J, AU - Pilowsky,P, PY - 1996/7/8/pubmed PY - 1996/7/8/medline PY - 1996/7/8/entrez SP - 64 EP - 8 JF - Brain research JO - Brain Res VL - 726 IS - 1-2 N2 - Previous studies have reported that information from carotid chemoreceptors activates sympathetic premotor neurons in the rostral ventrolateral medulla (RVLM) exclusively via N-methyl-D-aspartic acid (NMDA) receptors. In this study, we examined the possible involvement of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors in the RVLM on sympathetic chemoreceptor reflex in pentobarbitone anaesthetised, vagotomised and artificially ventilated rats. Carotid chemoreceptor stimulation with brief N2 inhalation increased splanchnic sympathetic nerve activity and arterial pressure in animals that had received an intravenous injection of the non-competitive NMDA receptor blocker, MK-801 (2 mg/kg). RVLM sympathetic premotor neurons could also be activated by brief hypoxia in the presence of MK-801. However, microinjection of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, a selective AMPA/kainate receptor antagonist, 2 mM, 100 nl) into the RVLM after intravenous MK-801 abolished the hypoxia evoked sympathoexcitatory response. These results demonstrate that AMPA/kainate receptors in the RVLM are involved in the chemoreceptor reflex pathway. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/8836546/AMPA/kainate_receptors_mediate_sympathetic_chemoreceptor_reflex_in_the_rostral_ventrolateral_medulla_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(96)00272-7 DB - PRIME DP - Unbound Medicine ER -