Tags

Type your tag names separated by a space and hit enter

A comparative study of the effects of the hemostatic system of two monophasic gestodene oral contraceptives containing 20 micrograms and 30 micrograms ethinylestradiol.
Contraception. 1996 Feb; 53(2):75-84.C

Abstract

The effects of two oral contraceptives, containing gestodene and either 20 micrograms or 30 micrograms ethinylestradiol, on hemostatic parameters was investigated in a six-month randomized study involving a total of 40 healthy women between the ages of 18 and 30 years. A large number of hemostatic parameters were measured, which were categorized as either pro-coagulatory, anti-coagulatory, profibrinolytic, anti-fibrinolytic or indicative of fibrin turnover. Additionally, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) were measured before and after venous occlusion and delta and ratio values calculated. Pro-coagulatory factors as well as reaction products reflecting in vivo coagulatory activity (thrombin-antithrombin III complex, prothrombin fragment 1 + 2) were found to increase. Among the anti-coagulatory parameters, only protein S concentration and protein S activity decreased, most notably in the 30 micrograms EE group. There was a corresponding increase in fibrinolytic activity reflected by reaction products of in vivo fibrinolysis (plasmin-antiplasmin 2-complex, fibrin-degradation products). Measurement of t-PA and PAI-1, before and after venous occlusion, revealed that the fibrinolytic response was more pronounced in the 20 micrograms EE group. There was also an increase in the threshold of fibrinolytic inhibition (ratio PAI-1) in both groups, which was less pronounced in the 20 micrograms EE group. Apart from isolated measurements, all parameters remained within their normal ranges and values returned to baseline in the follow-up cycle. It is concluded that both preparations had a balanced effect on the hemostatic system stimulating both pro-coagulant and fibrinolytic activity. No statistically significant differences were observed between the two groups; however, there was a trend towards greater fibrinolytic capacity in the 20 micrograms EE group.

Authors+Show Affiliations

University Hospital Essen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8838483

Citation

Winkler, U H., et al. "A Comparative Study of the Effects of the Hemostatic System of Two Monophasic Gestodene Oral Contraceptives Containing 20 Micrograms and 30 Micrograms Ethinylestradiol." Contraception, vol. 53, no. 2, 1996, pp. 75-84.
Winkler UH, Schindler AE, Endrikat J, et al. A comparative study of the effects of the hemostatic system of two monophasic gestodene oral contraceptives containing 20 micrograms and 30 micrograms ethinylestradiol. Contraception. 1996;53(2):75-84.
Winkler, U. H., Schindler, A. E., Endrikat, J., & Düsterberg, B. (1996). A comparative study of the effects of the hemostatic system of two monophasic gestodene oral contraceptives containing 20 micrograms and 30 micrograms ethinylestradiol. Contraception, 53(2), 75-84.
Winkler UH, et al. A Comparative Study of the Effects of the Hemostatic System of Two Monophasic Gestodene Oral Contraceptives Containing 20 Micrograms and 30 Micrograms Ethinylestradiol. Contraception. 1996;53(2):75-84. PubMed PMID: 8838483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study of the effects of the hemostatic system of two monophasic gestodene oral contraceptives containing 20 micrograms and 30 micrograms ethinylestradiol. AU - Winkler,U H, AU - Schindler,A E, AU - Endrikat,J, AU - Düsterberg,B, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez KW - Biology KW - Blood Coagulation Effects KW - Clinical Research KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Developed Countries KW - Ethinyl Estradiol KW - Europe KW - Family Planning KW - Fibrinolysis KW - Germany KW - Gestodene KW - Hematological Effects KW - Hemic System KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Physiology KW - Research Methodology KW - Research Report KW - Studies KW - Western Europe SP - 75 EP - 84 JF - Contraception JO - Contraception VL - 53 IS - 2 N2 - The effects of two oral contraceptives, containing gestodene and either 20 micrograms or 30 micrograms ethinylestradiol, on hemostatic parameters was investigated in a six-month randomized study involving a total of 40 healthy women between the ages of 18 and 30 years. A large number of hemostatic parameters were measured, which were categorized as either pro-coagulatory, anti-coagulatory, profibrinolytic, anti-fibrinolytic or indicative of fibrin turnover. Additionally, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) were measured before and after venous occlusion and delta and ratio values calculated. Pro-coagulatory factors as well as reaction products reflecting in vivo coagulatory activity (thrombin-antithrombin III complex, prothrombin fragment 1 + 2) were found to increase. Among the anti-coagulatory parameters, only protein S concentration and protein S activity decreased, most notably in the 30 micrograms EE group. There was a corresponding increase in fibrinolytic activity reflected by reaction products of in vivo fibrinolysis (plasmin-antiplasmin 2-complex, fibrin-degradation products). Measurement of t-PA and PAI-1, before and after venous occlusion, revealed that the fibrinolytic response was more pronounced in the 20 micrograms EE group. There was also an increase in the threshold of fibrinolytic inhibition (ratio PAI-1) in both groups, which was less pronounced in the 20 micrograms EE group. Apart from isolated measurements, all parameters remained within their normal ranges and values returned to baseline in the follow-up cycle. It is concluded that both preparations had a balanced effect on the hemostatic system stimulating both pro-coagulant and fibrinolytic activity. No statistically significant differences were observed between the two groups; however, there was a trend towards greater fibrinolytic capacity in the 20 micrograms EE group. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/8838483/A_comparative_study_of_the_effects_of_the_hemostatic_system_of_two_monophasic_gestodene_oral_contraceptives_containing_20_micrograms_and_30_micrograms_ethinylestradiol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010782495002715 DB - PRIME DP - Unbound Medicine ER -