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Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target.
Cancer Res. 1996 Oct 15; 56(20):4570-4.CR

Abstract

The disappointingly low survival rate observed in Ewing's sarcoma (ES)/peripheral neuroectodermal tumor (PNET) despite the adoption of aggressive multimodal treatments prompted us to study the existence of autocrine circuits to be used as innovative therapeutic targets. Of the several circuits analyzed, only the insulin-like growth factor receptor (IGF-IR)-mediated loop was found to be constantly present both in cell lines and clinical samples, suggesting a role for this autocrine circuit in the pathogenesis of ES/PNET. The in vitro inhibition of the IGF-IR-mediated circuit by the specific IGF-IR binding antibody alphaIR3 suppressed the growth of ES/PNET cells by decreasing the proliferative rate and increasing apoptosis. alphaIR3 also significantly inhibited the ability of ES/PNET cells to grow in soft agar and to migrate following a chemotactic stimulus. Inactivation of the IGF-IR signaling pathway may therefore be considered as an effective therapeutic modality for patients with ES/PNET.

Authors+Show Affiliations

Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8840962

Citation

Scotlandi, K, et al. "Insulin-like Growth Factor I Receptor-mediated Circuit in Ewing's Sarcoma/peripheral Neuroectodermal Tumor: a Possible Therapeutic Target." Cancer Research, vol. 56, no. 20, 1996, pp. 4570-4.
Scotlandi K, Benini S, Sarti M, et al. Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target. Cancer Res. 1996;56(20):4570-4.
Scotlandi, K., Benini, S., Sarti, M., Serra, M., Lollini, P. L., Maurici, D., Picci, P., Manara, M. C., & Baldini, N. (1996). Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target. Cancer Research, 56(20), 4570-4.
Scotlandi K, et al. Insulin-like Growth Factor I Receptor-mediated Circuit in Ewing's Sarcoma/peripheral Neuroectodermal Tumor: a Possible Therapeutic Target. Cancer Res. 1996 Oct 15;56(20):4570-4. PubMed PMID: 8840962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target. AU - Scotlandi,K, AU - Benini,S, AU - Sarti,M, AU - Serra,M, AU - Lollini,P L, AU - Maurici,D, AU - Picci,P, AU - Manara,M C, AU - Baldini,N, PY - 1996/10/15/pubmed PY - 1996/10/15/medline PY - 1996/10/15/entrez SP - 4570 EP - 4 JF - Cancer research JO - Cancer Res VL - 56 IS - 20 N2 - The disappointingly low survival rate observed in Ewing's sarcoma (ES)/peripheral neuroectodermal tumor (PNET) despite the adoption of aggressive multimodal treatments prompted us to study the existence of autocrine circuits to be used as innovative therapeutic targets. Of the several circuits analyzed, only the insulin-like growth factor receptor (IGF-IR)-mediated loop was found to be constantly present both in cell lines and clinical samples, suggesting a role for this autocrine circuit in the pathogenesis of ES/PNET. The in vitro inhibition of the IGF-IR-mediated circuit by the specific IGF-IR binding antibody alphaIR3 suppressed the growth of ES/PNET cells by decreasing the proliferative rate and increasing apoptosis. alphaIR3 also significantly inhibited the ability of ES/PNET cells to grow in soft agar and to migrate following a chemotactic stimulus. Inactivation of the IGF-IR signaling pathway may therefore be considered as an effective therapeutic modality for patients with ES/PNET. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/8840962/Insulin_like_growth_factor_I_receptor_mediated_circuit_in_Ewing's_sarcoma/peripheral_neuroectodermal_tumor:_a_possible_therapeutic_target_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8840962 DB - PRIME DP - Unbound Medicine ER -