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Shorter pill-free interval in combined oral contraceptives decreases follicular development.
Contraception. 1996 Aug; 54(2):71-7.C

Abstract

The objective of the study was to determine the suppressive effect on ovarian activity of 20 micrograms ethinylestradiol plus 75 micrograms gestodene administered for 21 or 23 days. The study was designed as a double-blind, randomized, multicenter trial in 60 women. A pre-treatment cycle, three treatment cycles and a post-treatment period were monitored by ovarian ultrasound and by LH, FSH, 17 beta-estradiol and progesterone measurements every other day. No ovulation and no luteinized, unruptured follicle were observed. Suppression of ovarian activity was more pronounced by the 23-day regimen. 17 beta-Estradiol serum levels during the last six days of a cycle and during the first six days of the next cycle were significantly less (p < 0.05) in the 23-day regimen. The superiority of the 23-day regimen in comparison to the 21-day regimen with regard to the suppression of ovarian activity was shown in this study. The observed differences in the 17 beta-estradiol levels and follicular development between a 21-day and 23-day preparation combine to suggest that shortening the pill-free interval in combined oral contraceptives may increase the contraceptive safety margin in women on low-dose formulations.

Authors+Show Affiliations

First Department of Obstetrics and Gynecology, University of Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

8842582

Citation

Spona, J, et al. "Shorter Pill-free Interval in Combined Oral Contraceptives Decreases Follicular Development." Contraception, vol. 54, no. 2, 1996, pp. 71-7.
Spona J, Elstein M, Feichtinger W, et al. Shorter pill-free interval in combined oral contraceptives decreases follicular development. Contraception. 1996;54(2):71-7.
Spona, J., Elstein, M., Feichtinger, W., Sullivan, H., Lüdicke, F., Müller, U., & Düsterberg, B. (1996). Shorter pill-free interval in combined oral contraceptives decreases follicular development. Contraception, 54(2), 71-7.
Spona J, et al. Shorter Pill-free Interval in Combined Oral Contraceptives Decreases Follicular Development. Contraception. 1996;54(2):71-7. PubMed PMID: 8842582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Shorter pill-free interval in combined oral contraceptives decreases follicular development. AU - Spona,J, AU - Elstein,M, AU - Feichtinger,W, AU - Sullivan,H, AU - Lüdicke,F, AU - Müller,U, AU - Düsterberg,B, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez KW - Austria KW - Biology KW - Clinical Research KW - Clinical Trials KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Developed Countries KW - Endocrine System KW - Ethinyl Estradiol KW - Europe KW - Family Planning KW - Genitalia KW - Genitalia, Female KW - Gestodene KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Human Volunteers KW - Luteinizing Hormone KW - Northern Europe KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Ovarian Effects KW - Ovary KW - Physiology KW - Research Methodology KW - Research Report KW - United Kingdom KW - Urogenital System KW - Western Europe SP - 71 EP - 7 JF - Contraception JO - Contraception VL - 54 IS - 2 N2 - The objective of the study was to determine the suppressive effect on ovarian activity of 20 micrograms ethinylestradiol plus 75 micrograms gestodene administered for 21 or 23 days. The study was designed as a double-blind, randomized, multicenter trial in 60 women. A pre-treatment cycle, three treatment cycles and a post-treatment period were monitored by ovarian ultrasound and by LH, FSH, 17 beta-estradiol and progesterone measurements every other day. No ovulation and no luteinized, unruptured follicle were observed. Suppression of ovarian activity was more pronounced by the 23-day regimen. 17 beta-Estradiol serum levels during the last six days of a cycle and during the first six days of the next cycle were significantly less (p < 0.05) in the 23-day regimen. The superiority of the 23-day regimen in comparison to the 21-day regimen with regard to the suppression of ovarian activity was shown in this study. The observed differences in the 17 beta-estradiol levels and follicular development between a 21-day and 23-day preparation combine to suggest that shortening the pill-free interval in combined oral contraceptives may increase the contraceptive safety margin in women on low-dose formulations. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/8842582/Shorter_pill_free_interval_in_combined_oral_contraceptives_decreases_follicular_development_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010782496001370 DB - PRIME DP - Unbound Medicine ER -