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Micronuclei induction by carboplatin in human lymphocyte subpopulations.

Abstract

Micronuclei (MN) induction by carboplatin, cis-diammine-1,1-cyclobutane decarboxylate platinum (II) (CBDCA), in B and T lymphocytes was studied by the MAC (morphology/antibody/chromosome) method which allows the immunologic identification of different cell lineages. An increased frequency of MN in B and T lymphocytes in CBDCA-treated cultures compared with controls was observed (p < 0.001). CBD cells were found to be more sensitive to CBDCA damage. CBDCA-treated cultures showed a decrease, albeit statistically non-significant, in the proportion of CBD interphasic and mitotic cells. Furthermore, higher MN frequencies in isolated lymphocytes than in whole blood in both control and CBDCA-treated cultures were observed.

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    Source

    Anti-cancer drugs 6:6 1995 Dec pg 758-62

    MeSH

    Adult
    Antineoplastic Agents
    B-Lymphocytes
    Carboplatin
    Cells, Cultured
    Humans
    Immunoenzyme Techniques
    Lymphocytes
    Male
    Micronuclei, Chromosome-Defective
    Micronucleus Tests
    Middle Aged
    Mitosis
    T-Lymphocytes

    Pub Type(s)

    In Vitro
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8845488