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Risk assessment and other screening options for gonorrhoea and chlamydial infections in women attending rural Tanzanian antenatal clinics.
Bull World Health Organ. 1995; 73(5):621-30.BW

Abstract

Sexually transmitted diseases (STDs) are a major cause of morbidity and mortality in developing countries and may play a key role in enhancing the heterosexual transmission of human immunodeficiency virus (HIV). Treatment of STDs is one of the most cost-effective of all health interventions in developing countries; however, STDs among women in rural populations have received little attention. In this study, we report that prevalences of STDs among 964 women attending antenatal clinics in a rural area of the United Republic of Tanzania. A total of 378 (39%) of these women were infected with at least one STD pathogen, 97 (10%) had syphilis, and 81 (8%) has Neisseria gonorrhoeae (NG) and/or Chlamydia trachomatis (CT) infection. The recommended syndromic approach to screening for NG/CT infection, based on reported genital symptoms, had a low sensitivity (43%) and failed to discriminate between infected and uninfected women. A risk score approach that we developed, based on sociodemographic and other factors associated with NG/CT infection, had a higher sensitivity and lower cost per true case treated than other approaches, although its positive predictive value was only about 20%.

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Authors+Show Affiliations

Mayaud P
Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, England.
Grosskurth H
No affiliation info available
Changalucha J
No affiliation info available
Todd J
No affiliation info available
West B
No affiliation info available
Gabone R
No affiliation info available
Senkoro K
No affiliation info available
Rusizoka M
No affiliation info available
Laga M
No affiliation info available
Hayes R
No affiliation info available

MeSH

AdultChlamydia InfectionsChlamydia trachomatisCost-Benefit AnalysisFemaleGonorrheaHumansMass ScreeningPregnancyPregnancy Complications, InfectiousPrenatal CarePrevalenceRisk AssessmentRural HealthSensitivity and SpecificityTanzania

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8846488

Citation

Mayaud, P, et al. "Risk Assessment and Other Screening Options for Gonorrhoea and Chlamydial Infections in Women Attending Rural Tanzanian Antenatal Clinics." Bulletin of the World Health Organization, vol. 73, no. 5, 1995, pp. 621-30.
Mayaud P, Grosskurth H, Changalucha J, et al. Risk assessment and other screening options for gonorrhoea and chlamydial infections in women attending rural Tanzanian antenatal clinics. Bull World Health Organ. 1995;73(5):621-30.
Mayaud, P., Grosskurth, H., Changalucha, J., Todd, J., West, B., Gabone, R., Senkoro, K., Rusizoka, M., Laga, M., & Hayes, R. (1995). Risk assessment and other screening options for gonorrhoea and chlamydial infections in women attending rural Tanzanian antenatal clinics. Bulletin of the World Health Organization, 73(5), 621-30.
Mayaud P, et al. Risk Assessment and Other Screening Options for Gonorrhoea and Chlamydial Infections in Women Attending Rural Tanzanian Antenatal Clinics. Bull World Health Organ. 1995;73(5):621-30. PubMed PMID: 8846488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk assessment and other screening options for gonorrhoea and chlamydial infections in women attending rural Tanzanian antenatal clinics. A1 - Mayaud,P, AU - Grosskurth,H, AU - Changalucha,J, AU - Todd,J, AU - West,B, AU - Gabone,R, AU - Senkoro,K, AU - Rusizoka,M, AU - Laga,M, AU - Hayes,R, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez KW - Africa KW - Africa South Of The Sahara KW - Chlamydia KW - Cost Effectiveness KW - Developing Countries KW - Diseases KW - Eastern Africa KW - English Speaking Africa KW - Evaluation KW - Evaluation Indexes KW - Evaluation Report KW - Examinations And Diagnoses KW - Gonorrhea KW - Infections KW - Measurement KW - Quantitative Evaluation KW - Reliability KW - Reproductive Tract Infections KW - Research Methodology KW - Risk Assessment KW - Screening KW - Sexually Transmitted Diseases KW - Signs And Symptoms KW - Tanzania SP - 621 EP - 30 JF - Bulletin of the World Health Organization JO - Bull World Health Organ VL - 73 IS - 5 N2 - Sexually transmitted diseases (STDs) are a major cause of morbidity and mortality in developing countries and may play a key role in enhancing the heterosexual transmission of human immunodeficiency virus (HIV). Treatment of STDs is one of the most cost-effective of all health interventions in developing countries; however, STDs among women in rural populations have received little attention. In this study, we report that prevalences of STDs among 964 women attending antenatal clinics in a rural area of the United Republic of Tanzania. A total of 378 (39%) of these women were infected with at least one STD pathogen, 97 (10%) had syphilis, and 81 (8%) has Neisseria gonorrhoeae (NG) and/or Chlamydia trachomatis (CT) infection. The recommended syndromic approach to screening for NG/CT infection, based on reported genital symptoms, had a low sensitivity (43%) and failed to discriminate between infected and uninfected women. A risk score approach that we developed, based on sociodemographic and other factors associated with NG/CT infection, had a higher sensitivity and lower cost per true case treated than other approaches, although its positive predictive value was only about 20%. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/8846488/Risk_assessment_and_other_screening_options_for_gonorrhoea_and_chlamydial_infections_in_women_attending_rural_Tanzanian_antenatal_clinics_ DB - PRIME DP - Unbound Medicine ER -