Tags

Type your tag names separated by a space and hit enter

Angiotensin converting enzyme (ACE) inhibitors and kinin metabolism: evidence that ACE inhibitors may inhibit a kininase other than ACE.
Clin Exp Pharmacol Physiol. 1995 Dec; 22(12):903-11.CE

Abstract

1. Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, and also metabolizes bradykinin-(1-9) to bradykinin-(1-7) and bradykinin-(1-7) to bradykinin-(1-5). Increases in endogenous kinin levels may contribute to the therapeutic effects of ACE inhibitors. 2. ACE inhibitors increase vascular levels of both bradykinin-(1-9) and its ACE cleavage product bradykinin-(1-7), at doses below the threshold for ACE inhibition, leading to the proposal that ACE inhibitors may also inhibit a non-ACE kininase which cleaves both kinin peptides; this non-ACE kininase may be the major pathway of kinin metabolism in the vasculature and some other tissues. 3. In support of this proposal, ACE inhibitors potentiate bradykinin-(1-9) effects at doses which have little or no effect on ACE activity, as indicated by angiotensin I conversion to angiotensin II. ACE inhibitors also potentiate the actions of ACE-resistant kinin analogues, which may be susceptible to metabolism by a non-ACE kininase. 4. Identification and characterization of the putative non-ACE kininase which is inhibited by ACE inhibitors may reveal novel approaches to the tissue-specific modulation of kinin levels.

Authors+Show Affiliations

St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8846511

Citation

Campbell, D J.. "Angiotensin Converting Enzyme (ACE) Inhibitors and Kinin Metabolism: Evidence That ACE Inhibitors May Inhibit a Kininase Other Than ACE." Clinical and Experimental Pharmacology & Physiology, vol. 22, no. 12, 1995, pp. 903-11.
Campbell DJ. Angiotensin converting enzyme (ACE) inhibitors and kinin metabolism: evidence that ACE inhibitors may inhibit a kininase other than ACE. Clin Exp Pharmacol Physiol. 1995;22(12):903-11.
Campbell, D. J. (1995). Angiotensin converting enzyme (ACE) inhibitors and kinin metabolism: evidence that ACE inhibitors may inhibit a kininase other than ACE. Clinical and Experimental Pharmacology & Physiology, 22(12), 903-11.
Campbell DJ. Angiotensin Converting Enzyme (ACE) Inhibitors and Kinin Metabolism: Evidence That ACE Inhibitors May Inhibit a Kininase Other Than ACE. Clin Exp Pharmacol Physiol. 1995;22(12):903-11. PubMed PMID: 8846511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin converting enzyme (ACE) inhibitors and kinin metabolism: evidence that ACE inhibitors may inhibit a kininase other than ACE. A1 - Campbell,D J, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 903 EP - 11 JF - Clinical and experimental pharmacology & physiology JO - Clin. Exp. Pharmacol. Physiol. VL - 22 IS - 12 N2 - 1. Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, and also metabolizes bradykinin-(1-9) to bradykinin-(1-7) and bradykinin-(1-7) to bradykinin-(1-5). Increases in endogenous kinin levels may contribute to the therapeutic effects of ACE inhibitors. 2. ACE inhibitors increase vascular levels of both bradykinin-(1-9) and its ACE cleavage product bradykinin-(1-7), at doses below the threshold for ACE inhibition, leading to the proposal that ACE inhibitors may also inhibit a non-ACE kininase which cleaves both kinin peptides; this non-ACE kininase may be the major pathway of kinin metabolism in the vasculature and some other tissues. 3. In support of this proposal, ACE inhibitors potentiate bradykinin-(1-9) effects at doses which have little or no effect on ACE activity, as indicated by angiotensin I conversion to angiotensin II. ACE inhibitors also potentiate the actions of ACE-resistant kinin analogues, which may be susceptible to metabolism by a non-ACE kininase. 4. Identification and characterization of the putative non-ACE kininase which is inhibited by ACE inhibitors may reveal novel approaches to the tissue-specific modulation of kinin levels. SN - 0305-1870 UR - https://www.unboundmedicine.com/medline/citation/8846511/Angiotensin_converting_enzyme__ACE__inhibitors_and_kinin_metabolism:_evidence_that_ACE_inhibitors_may_inhibit_a_kininase_other_than_ACE_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0305-1870&date=1995&volume=22&issue=12&spage=903 DB - PRIME DP - Unbound Medicine ER -