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Protective effects of carvedilol, a vasodilating beta-adrenoceptor blocker, against in vivo low density lipoprotein oxidation in essential hypertension.
J Cardiovasc Pharmacol. 1996 Apr; 27(4):532-8.JC

Abstract

Low density lipoprotein (LDL) oxidation plays a crucial role in the development and progression of atherosclerosis and is enhanced in patients with essential hypertension. This finding has stimulated a search for antihypertensive drugs with high intrinsic antioxidant properties. We investigated the antihypertensive and antioxidant effects of carvedilol, a new vasodilating beta-adrenoceptor blocking agent in a group of patients with mild to moderate essential hypertension after 4-month treatment. Carvedilol administration markedly increased the resistance to oxidation of LDL isolated from treated patients to values comparable to those of control, nonhypertensive subjects. This effect was achieved despite a significant loss in LDL-associated vitamin E. The increased resistance of LDL to oxidation promoted by carvedilol was not related to the normalization of previously increased blood pressure (BP). Indeed, the administration of other conventional antihypertensive drugs, capable of decreasing arterial BP but without high intrinsic antioxidant properties, to a control group of matched hypertensive patients failed to ameliorate LDL oxidation parameters. Carvedilol treatment also reduced the extent of in vivo LDL oxidation, as reflected by the decrease in antioxidized LDL autoantibody titer. This effect as well was detected only in the group of carvedilol-treated hypertensive patients and not after the simple reduction in BP obtained with antihypertensive drugs different from carvedilol.

Authors+Show Affiliations

Department of Internal Medicine, University of Pavia, IRCCS Policlinico S. Matteo, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8847870

Citation

Maggi, E, et al. "Protective Effects of Carvedilol, a Vasodilating Beta-adrenoceptor Blocker, Against in Vivo Low Density Lipoprotein Oxidation in Essential Hypertension." Journal of Cardiovascular Pharmacology, vol. 27, no. 4, 1996, pp. 532-8.
Maggi E, Marchesi E, Covini D, et al. Protective effects of carvedilol, a vasodilating beta-adrenoceptor blocker, against in vivo low density lipoprotein oxidation in essential hypertension. J Cardiovasc Pharmacol. 1996;27(4):532-8.
Maggi, E., Marchesi, E., Covini, D., Negro, C., Perani, G., & Bellomo, G. (1996). Protective effects of carvedilol, a vasodilating beta-adrenoceptor blocker, against in vivo low density lipoprotein oxidation in essential hypertension. Journal of Cardiovascular Pharmacology, 27(4), 532-8.
Maggi E, et al. Protective Effects of Carvedilol, a Vasodilating Beta-adrenoceptor Blocker, Against in Vivo Low Density Lipoprotein Oxidation in Essential Hypertension. J Cardiovasc Pharmacol. 1996;27(4):532-8. PubMed PMID: 8847870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of carvedilol, a vasodilating beta-adrenoceptor blocker, against in vivo low density lipoprotein oxidation in essential hypertension. AU - Maggi,E, AU - Marchesi,E, AU - Covini,D, AU - Negro,C, AU - Perani,G, AU - Bellomo,G, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 532 EP - 8 JF - Journal of cardiovascular pharmacology JO - J Cardiovasc Pharmacol VL - 27 IS - 4 N2 - Low density lipoprotein (LDL) oxidation plays a crucial role in the development and progression of atherosclerosis and is enhanced in patients with essential hypertension. This finding has stimulated a search for antihypertensive drugs with high intrinsic antioxidant properties. We investigated the antihypertensive and antioxidant effects of carvedilol, a new vasodilating beta-adrenoceptor blocking agent in a group of patients with mild to moderate essential hypertension after 4-month treatment. Carvedilol administration markedly increased the resistance to oxidation of LDL isolated from treated patients to values comparable to those of control, nonhypertensive subjects. This effect was achieved despite a significant loss in LDL-associated vitamin E. The increased resistance of LDL to oxidation promoted by carvedilol was not related to the normalization of previously increased blood pressure (BP). Indeed, the administration of other conventional antihypertensive drugs, capable of decreasing arterial BP but without high intrinsic antioxidant properties, to a control group of matched hypertensive patients failed to ameliorate LDL oxidation parameters. Carvedilol treatment also reduced the extent of in vivo LDL oxidation, as reflected by the decrease in antioxidized LDL autoantibody titer. This effect as well was detected only in the group of carvedilol-treated hypertensive patients and not after the simple reduction in BP obtained with antihypertensive drugs different from carvedilol. SN - 0160-2446 UR - https://www.unboundmedicine.com/medline/citation/8847870/Protective_effects_of_carvedilol_a_vasodilating_beta_adrenoceptor_blocker_against_in_vivo_low_density_lipoprotein_oxidation_in_essential_hypertension_ L2 - https://doi.org/10.1097/00005344-199604000-00012 DB - PRIME DP - Unbound Medicine ER -