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Pharmacologic evaluation of the discriminative stimulus of metachlorophenylpiperazine.
Pharmacol Biochem Behav. 1996 Jan; 53(1):107-14.PB

Abstract

A pharmacologic analysis of the discriminative stimulus of metachlorophenylpiperazine (mCPP) is reported. mCPP and m-trifluoromethylphenylpiperazine generalised, whereas 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole, 6-chloro-2-(1-piperazinyl)-pyrazine, and mesulergine partially generalised to the mCPP discriminative cue. However, although mianserin, methiothepin, ritanserin, mesulergine and N-(1-methyl-5'-indolyl)-N'-(3-pyridyl)urea hydrochloride (SB 200646) all antagonised the effect of 5-hydroxytryptamine (5-HT) on IP3 formation in the rat choroid plexus, they failed to antagonise the mCPP response in the drug discrimination studies. The 5-HT3 receptor antagonist MDL 72222 neither generalised nor antagonised the mCPP cue. These data suggest that neither the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5, 5-HT6, nor 5-HT7 receptors are involved. The response does appear to be mediated by a postsynaptic 5-HT receptor, however, because fenfluramine generalised to the cue. Haloperidol generalises, and amphetamine partially antagonises the mCPP discriminative cue and low doses of apomorphine partially generalises to the mCPP cue, which suggests that a decrease in dopamine neurotransmission may also be involved.

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Authors+Show Affiliations

Bourson A
Pharma Division, F. Hoffmann-La Roche Ltd, Switzerland.
Wanner D
No affiliation info available
Wyler R
No affiliation info available
Petit N
No affiliation info available
Zwingelstein C
No affiliation info available
Rudler A
No affiliation info available
Sleight AJ
No affiliation info available

MeSH

AmphetamineAnimalsCentral Nervous System StimulantsChoroid PlexusCuesDiscrimination, PsychologicalGeneralization, StimulusIndolesInositol 1,4,5-TrisphosphateMalePiperazinesRatsRats, Sprague-DawleyReceptors, SerotoninSerotonin AntagonistsSerotonin Receptor AgonistsUrea

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8848438

Citation

Bourson, A, et al. "Pharmacologic Evaluation of the Discriminative Stimulus of Metachlorophenylpiperazine." Pharmacology, Biochemistry, and Behavior, vol. 53, no. 1, 1996, pp. 107-14.
Bourson A, Wanner D, Wyler R, et al. Pharmacologic evaluation of the discriminative stimulus of metachlorophenylpiperazine. Pharmacol Biochem Behav. 1996;53(1):107-14.
Bourson, A., Wanner, D., Wyler, R., Petit, N., Zwingelstein, C., Rudler, A., & Sleight, A. J. (1996). Pharmacologic evaluation of the discriminative stimulus of metachlorophenylpiperazine. Pharmacology, Biochemistry, and Behavior, 53(1), 107-14.
Bourson A, et al. Pharmacologic Evaluation of the Discriminative Stimulus of Metachlorophenylpiperazine. Pharmacol Biochem Behav. 1996;53(1):107-14. PubMed PMID: 8848438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacologic evaluation of the discriminative stimulus of metachlorophenylpiperazine. AU - Bourson,A, AU - Wanner,D, AU - Wyler,R, AU - Petit,N, AU - Zwingelstein,C, AU - Rudler,A, AU - Sleight,A J, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 107 EP - 14 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 53 IS - 1 N2 - A pharmacologic analysis of the discriminative stimulus of metachlorophenylpiperazine (mCPP) is reported. mCPP and m-trifluoromethylphenylpiperazine generalised, whereas 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole, 6-chloro-2-(1-piperazinyl)-pyrazine, and mesulergine partially generalised to the mCPP discriminative cue. However, although mianserin, methiothepin, ritanserin, mesulergine and N-(1-methyl-5'-indolyl)-N'-(3-pyridyl)urea hydrochloride (SB 200646) all antagonised the effect of 5-hydroxytryptamine (5-HT) on IP3 formation in the rat choroid plexus, they failed to antagonise the mCPP response in the drug discrimination studies. The 5-HT3 receptor antagonist MDL 72222 neither generalised nor antagonised the mCPP cue. These data suggest that neither the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5, 5-HT6, nor 5-HT7 receptors are involved. The response does appear to be mediated by a postsynaptic 5-HT receptor, however, because fenfluramine generalised to the cue. Haloperidol generalises, and amphetamine partially antagonises the mCPP discriminative cue and low doses of apomorphine partially generalises to the mCPP cue, which suggests that a decrease in dopamine neurotransmission may also be involved. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/8848438/Pharmacologic_evaluation_of_the_discriminative_stimulus_of_metachlorophenylpiperazine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(95)00207-3 DB - PRIME DP - Unbound Medicine ER -