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[The immunogenicity of vaccines against diphtheria, tetanus, pertussis and polio administered orally on the vaccinal calendar at the age of 2, 4 and 6 months and their coadministration with a hepatitis B vaccine at 0, 2 and 6 months].
An Esp Pediatr. 1996 Jan; 44(1):25-8.AE

Abstract

The immunogenicity of oral diphtheria, pertussis, tetanus, (DPT) and polio vaccines was examined. Six hundred seventy-seven children (Group I) were given hepatitis B vaccine at 0, 2, and 6 months of age and the oral DPT-polio vaccines were administered at 2, 4 and 6 months of age. A control group of 731 children (Group II) received only oral DPT-polio vaccines. In both groups the vaccine efficacy against poliomyelitis was 96% for serotype I and 100% for serotype II. For serotype III, the vaccine efficacy was 98% and 97% for groups I and II, respectively. In both groups 97% of the children had antibodies against B. pertussis and all children were positive for tetanus and diphtheria. No immune interference between the oral DPT and polio vaccines and the hepatitis B vaccine when they were given simultaneously could be demonstrated as the immune response to the DPT and polio vaccines were identical in both groups. It can be concluded that the simultaneous administration of the hepatitis B vaccine with the DPT and polio vaccines did not interfere with the immune response to the other antigens.

Authors+Show Affiliations

Arístegui Fernández J
Departamento de Pediatría, Hospital de Basurto, Bilbao.
Muñiz Saitua J
No affiliation info available
Pérez Legorburu A
No affiliation info available
Imaz Pérez M
No affiliation info available
Arrate Zugazabeitia JP
No affiliation info available
Suárez Fernández MD
No affiliation info available
Goiri Zabala MD
No affiliation info available

MeSH

Administration, OralAgingAntibodies, BacterialAntibodies, ViralBordetella pertussisClostridium tetaniCorynebacterium diphtheriaeDiphtheria-Tetanus-Pertussis VaccineHepatitis B AntibodiesHepatitis B VaccinesHumansImmunization ScheduleInfantInfant, NewbornPoliovirusPoliovirus Vaccine, Oral

Pub Type(s)

Comparative Study
Journal Article

Language

spa

PubMed ID

8849056

Citation

Arístegui Fernández, J, et al. "[The Immunogenicity of Vaccines Against Diphtheria, Tetanus, Pertussis and Polio Administered Orally On the Vaccinal Calendar at the Age of 2, 4 and 6 Months and Their Coadministration With a Hepatitis B Vaccine at 0, 2 and 6 Months]." Anales Espanoles De Pediatria, vol. 44, no. 1, 1996, pp. 25-8.
Arístegui Fernández J, Muñiz Saitua J, Pérez Legorburu A, et al. [The immunogenicity of vaccines against diphtheria, tetanus, pertussis and polio administered orally on the vaccinal calendar at the age of 2, 4 and 6 months and their coadministration with a hepatitis B vaccine at 0, 2 and 6 months]. An Esp Pediatr. 1996;44(1):25-8.
Arístegui Fernández, J., Muñiz Saitua, J., Pérez Legorburu, A., Imaz Pérez, M., Arrate Zugazabeitia, J. P., Suárez Fernández, M. D., & Goiri Zabala, M. D. (1996). [The immunogenicity of vaccines against diphtheria, tetanus, pertussis and polio administered orally on the vaccinal calendar at the age of 2, 4 and 6 months and their coadministration with a hepatitis B vaccine at 0, 2 and 6 months]. Anales Espanoles De Pediatria, 44(1), 25-8.
Arístegui Fernández J, et al. [The Immunogenicity of Vaccines Against Diphtheria, Tetanus, Pertussis and Polio Administered Orally On the Vaccinal Calendar at the Age of 2, 4 and 6 Months and Their Coadministration With a Hepatitis B Vaccine at 0, 2 and 6 Months]. An Esp Pediatr. 1996;44(1):25-8. PubMed PMID: 8849056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The immunogenicity of vaccines against diphtheria, tetanus, pertussis and polio administered orally on the vaccinal calendar at the age of 2, 4 and 6 months and their coadministration with a hepatitis B vaccine at 0, 2 and 6 months]. AU - Arístegui Fernández,J, AU - Muñiz Saitua,J, AU - Pérez Legorburu,A, AU - Imaz Pérez,M, AU - Arrate Zugazabeitia,J P, AU - Suárez Fernández,M D, AU - Goiri Zabala,M D, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 25 EP - 8 JF - Anales espanoles de pediatria JO - An Esp Pediatr VL - 44 IS - 1 N2 - The immunogenicity of oral diphtheria, pertussis, tetanus, (DPT) and polio vaccines was examined. Six hundred seventy-seven children (Group I) were given hepatitis B vaccine at 0, 2, and 6 months of age and the oral DPT-polio vaccines were administered at 2, 4 and 6 months of age. A control group of 731 children (Group II) received only oral DPT-polio vaccines. In both groups the vaccine efficacy against poliomyelitis was 96% for serotype I and 100% for serotype II. For serotype III, the vaccine efficacy was 98% and 97% for groups I and II, respectively. In both groups 97% of the children had antibodies against B. pertussis and all children were positive for tetanus and diphtheria. No immune interference between the oral DPT and polio vaccines and the hepatitis B vaccine when they were given simultaneously could be demonstrated as the immune response to the DPT and polio vaccines were identical in both groups. It can be concluded that the simultaneous administration of the hepatitis B vaccine with the DPT and polio vaccines did not interfere with the immune response to the other antigens. SN - 0302-4342 UR - https://www.unboundmedicine.com/medline/citation/8849056/[The_immunogenicity_of_vaccines_against_diphtheria_tetanus_pertussis_and_polio_administered_orally_on_the_vaccinal_calendar_at_the_age_of_2_4_and_6_months_and_their_coadministration_with_a_hepatitis_B_vaccine_at_0_2_and_6_months]_ L2 - http://www.diseaseinfosearch.org/result/2292 DB - PRIME DP - Unbound Medicine ER -

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