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Detection of serum HBV DNA and anti-HCV antibody in HBsAg seronegative patients with hepatocellular carcinoma in Japan.
Kansenshogaku Zasshi 1996; 70(2):103-7KZ

Abstract

One hundred eight patients with hepatocellular carcinoma (HCC) underwent serologic testing for HBsAg, antibodies to HBs (anti-HBs), HBc (anti-HBc) and HCV (anti-HCV), and an assay for hepatitis B virus (HBV) DNA by the polymerase chain reaction (PCR). Ten (9.3%) of the 108 patients were positive for HBsAg and 96 (88.8%) were positive for anti-HCV. Both HBsAg and anti-HCV were present in 4 (3.7%) of the 108 patients. HBV DNA was detected in the serum of all patients who were positive for HBsAg and 9 (9.2%) of the 98 patients who were HBsAg-negative. Anti-HBc was positive and anti-HBs was negative in 8 of these 9 HBsAg negative patients with HBV DNA. HBsAg, HBV DNA and anti-HCV were negative in 6 (5.5%) of the 108 patients. These results suggest that HCV is highly associated with HCC and that HBV is occasionally associated with HCC even when HBsAg is negative.

Authors+Show Affiliations

Second Department of Medicine, Kurume University School of Medicine, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8851381

Citation

Tokeshi, S, et al. "Detection of Serum HBV DNA and anti-HCV Antibody in HBsAg Seronegative Patients With Hepatocellular Carcinoma in Japan." Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases, vol. 70, no. 2, 1996, pp. 103-7.
Tokeshi S, Sata M, Tanikawa K. Detection of serum HBV DNA and anti-HCV antibody in HBsAg seronegative patients with hepatocellular carcinoma in Japan. Kansenshogaku Zasshi. 1996;70(2):103-7.
Tokeshi, S., Sata, M., & Tanikawa, K. (1996). Detection of serum HBV DNA and anti-HCV antibody in HBsAg seronegative patients with hepatocellular carcinoma in Japan. Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases, 70(2), pp. 103-7.
Tokeshi S, Sata M, Tanikawa K. Detection of Serum HBV DNA and anti-HCV Antibody in HBsAg Seronegative Patients With Hepatocellular Carcinoma in Japan. Kansenshogaku Zasshi. 1996;70(2):103-7. PubMed PMID: 8851381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of serum HBV DNA and anti-HCV antibody in HBsAg seronegative patients with hepatocellular carcinoma in Japan. AU - Tokeshi,S, AU - Sata,M, AU - Tanikawa,K, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez SP - 103 EP - 7 JF - Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases JO - Kansenshogaku Zasshi VL - 70 IS - 2 N2 - One hundred eight patients with hepatocellular carcinoma (HCC) underwent serologic testing for HBsAg, antibodies to HBs (anti-HBs), HBc (anti-HBc) and HCV (anti-HCV), and an assay for hepatitis B virus (HBV) DNA by the polymerase chain reaction (PCR). Ten (9.3%) of the 108 patients were positive for HBsAg and 96 (88.8%) were positive for anti-HCV. Both HBsAg and anti-HCV were present in 4 (3.7%) of the 108 patients. HBV DNA was detected in the serum of all patients who were positive for HBsAg and 9 (9.2%) of the 98 patients who were HBsAg-negative. Anti-HBc was positive and anti-HBs was negative in 8 of these 9 HBsAg negative patients with HBV DNA. HBsAg, HBV DNA and anti-HCV were negative in 6 (5.5%) of the 108 patients. These results suggest that HCV is highly associated with HCC and that HBV is occasionally associated with HCC even when HBsAg is negative. SN - 0387-5911 UR - https://www.unboundmedicine.com/medline/citation/8851381/Detection_of_serum_HBV_DNA_and_anti_HCV_antibody_in_HBsAg_seronegative_patients_with_hepatocellular_carcinoma_in_Japan_ L2 - https://medlineplus.gov/livercancer.html DB - PRIME DP - Unbound Medicine ER -