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Association of bone mineral density with polymorphism of the estrogen receptor gene.
J Bone Miner Res. 1996 Mar; 11(3):306-11.JB

Abstract

PvuII and XbaI restriction fragment length polymorphisms (RFLPs) of the estrogen receptor (ER) gene and its relation to bone mineral density (BMD) were examined in 238 postmenopausal healthy women aged 45-91 years (66.3 +/- 0.6 years, mean +/- standard error of the mean [SEM]) in Japan. The RFLPs were represented as Pp (PvuII) and Xx (XbaI), with capital letters signifying the absence of and small letters the presence of restriction sites. In the PPxx genotype (n = 18), Z score values of BMD were significantly lower than those for other genotypes (n = 220) (lumbar spine, -0.746 vs. -0.065 [p = 0.022]; total body, -0.482 vs. 0.308 [p = 0.002]). We classified the subjects into three genotypes with allelic haplotype: homozygote of the Px haplotype was expressed as the 11 genotype, heterozygote of the Px haplotype as the 10 genotype, and the one lacking the Px haplotype as the 00 genotype. The PpXx genotype was not included in this analysis because the allelic haplotypes are uncertain. The Px haplotype was associated with a low BMD in postmenopausal women (Z score for the lumbar spine, -0.746 vs. -0.279 vs. 0.083, for the 11, 10, 00 genotypes, respectively [p = 0.029]; Z score for the total body, -0.482 vs. 0.164 vs. 0.427, respectively [p = 0.003]). We suggest that some variation of the ER gene linked to these RFLPs is associated with low BMD and that this at least partly explains the cause of postmenopausal osteoporosis in Japanese women.

Authors+Show Affiliations

Department of Geriatrics, University of Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8852941

Citation

Kobayashi, S, et al. "Association of Bone Mineral Density With Polymorphism of the Estrogen Receptor Gene." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 11, no. 3, 1996, pp. 306-11.
Kobayashi S, Inoue S, Hosoi T, et al. Association of bone mineral density with polymorphism of the estrogen receptor gene. J Bone Miner Res. 1996;11(3):306-11.
Kobayashi, S., Inoue, S., Hosoi, T., Ouchi, Y., Shiraki, M., & Orimo, H. (1996). Association of bone mineral density with polymorphism of the estrogen receptor gene. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 11(3), 306-11.
Kobayashi S, et al. Association of Bone Mineral Density With Polymorphism of the Estrogen Receptor Gene. J Bone Miner Res. 1996;11(3):306-11. PubMed PMID: 8852941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of bone mineral density with polymorphism of the estrogen receptor gene. AU - Kobayashi,S, AU - Inoue,S, AU - Hosoi,T, AU - Ouchi,Y, AU - Shiraki,M, AU - Orimo,H, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 306 EP - 11 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 11 IS - 3 N2 - PvuII and XbaI restriction fragment length polymorphisms (RFLPs) of the estrogen receptor (ER) gene and its relation to bone mineral density (BMD) were examined in 238 postmenopausal healthy women aged 45-91 years (66.3 +/- 0.6 years, mean +/- standard error of the mean [SEM]) in Japan. The RFLPs were represented as Pp (PvuII) and Xx (XbaI), with capital letters signifying the absence of and small letters the presence of restriction sites. In the PPxx genotype (n = 18), Z score values of BMD were significantly lower than those for other genotypes (n = 220) (lumbar spine, -0.746 vs. -0.065 [p = 0.022]; total body, -0.482 vs. 0.308 [p = 0.002]). We classified the subjects into three genotypes with allelic haplotype: homozygote of the Px haplotype was expressed as the 11 genotype, heterozygote of the Px haplotype as the 10 genotype, and the one lacking the Px haplotype as the 00 genotype. The PpXx genotype was not included in this analysis because the allelic haplotypes are uncertain. The Px haplotype was associated with a low BMD in postmenopausal women (Z score for the lumbar spine, -0.746 vs. -0.279 vs. 0.083, for the 11, 10, 00 genotypes, respectively [p = 0.029]; Z score for the total body, -0.482 vs. 0.164 vs. 0.427, respectively [p = 0.003]). We suggest that some variation of the ER gene linked to these RFLPs is associated with low BMD and that this at least partly explains the cause of postmenopausal osteoporosis in Japanese women. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/8852941/Association_of_bone_mineral_density_with_polymorphism_of_the_estrogen_receptor_gene_ L2 - https://doi.org/10.1002/jbmr.5650110304 DB - PRIME DP - Unbound Medicine ER -