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Antibodies to CagA protein are associated with gastric atrophy in Helicobacter pylori infection.
Eur J Gastroenterol Hepatol 1996; 8(7):645-9EJ

Abstract

Strains of Helicobacter pylori which express the product of the cytotoxin associated gene A(CagA) are associated with duodenal ulceration. Also there is evidence that the presence of serum IgG antibodies to CagA is associated with an increased risk of gastric cancer of the intestinal type. Gastric atrophy is a precursor of intestinal-type gastric cancer so we have investigated whether antibodies to CagA are associated with gastric atrophy. In H. pylori infected patients, IgG antibodies to CagA were present in 24/38 (63%) of non-ulcer patients with atrophy compared with 13/40 (33%) of patient-controls with neither atrophy nor ulcer (P < 0.02). CagA antibodies were also more prevalent in patients with duodenal ulcers; 15/20 (75%) or gastric ulcers 5/5 (100%) than in the patient-controls (P < 0.005 and < 0.02 respectively). These results show that circulating IgG antibodies to CagA are associated with gastric atrophy, as well as peptic ulcer disease. Atrophy is a precursor of gastric cancer so support the hypothesis that certain strains of H. pylori are more likely to cause gastric cancer.

Authors+Show Affiliations

Department of Medicine, Royal Postgraduate Medical School, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8853252

Citation

Beales, I L., et al. "Antibodies to CagA Protein Are Associated With Gastric Atrophy in Helicobacter Pylori Infection." European Journal of Gastroenterology & Hepatology, vol. 8, no. 7, 1996, pp. 645-9.
Beales IL, Crabtree JE, Scunes D, et al. Antibodies to CagA protein are associated with gastric atrophy in Helicobacter pylori infection. Eur J Gastroenterol Hepatol. 1996;8(7):645-9.
Beales, I. L., Crabtree, J. E., Scunes, D., Covacci, A., & Calam, J. (1996). Antibodies to CagA protein are associated with gastric atrophy in Helicobacter pylori infection. European Journal of Gastroenterology & Hepatology, 8(7), pp. 645-9.
Beales IL, et al. Antibodies to CagA Protein Are Associated With Gastric Atrophy in Helicobacter Pylori Infection. Eur J Gastroenterol Hepatol. 1996;8(7):645-9. PubMed PMID: 8853252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibodies to CagA protein are associated with gastric atrophy in Helicobacter pylori infection. AU - Beales,I L, AU - Crabtree,J E, AU - Scunes,D, AU - Covacci,A, AU - Calam,J, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 645 EP - 9 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 8 IS - 7 N2 - Strains of Helicobacter pylori which express the product of the cytotoxin associated gene A(CagA) are associated with duodenal ulceration. Also there is evidence that the presence of serum IgG antibodies to CagA is associated with an increased risk of gastric cancer of the intestinal type. Gastric atrophy is a precursor of intestinal-type gastric cancer so we have investigated whether antibodies to CagA are associated with gastric atrophy. In H. pylori infected patients, IgG antibodies to CagA were present in 24/38 (63%) of non-ulcer patients with atrophy compared with 13/40 (33%) of patient-controls with neither atrophy nor ulcer (P < 0.02). CagA antibodies were also more prevalent in patients with duodenal ulcers; 15/20 (75%) or gastric ulcers 5/5 (100%) than in the patient-controls (P < 0.005 and < 0.02 respectively). These results show that circulating IgG antibodies to CagA are associated with gastric atrophy, as well as peptic ulcer disease. Atrophy is a precursor of gastric cancer so support the hypothesis that certain strains of H. pylori are more likely to cause gastric cancer. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/8853252/Antibodies_to_CagA_protein_are_associated_with_gastric_atrophy_in_Helicobacter_pylori_infection_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -