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Cutaneous leishmaniasis: schedules for intralesional treatment with sodium stibogluconate.
Int J Dermatol. 1996 Aug; 35(8):594-7.IJ

Abstract

BACKGROUND

Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been investigated.

METHODS

Ninety-six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule.

RESULTS

The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate-day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%.

CONCLUSIONS

Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments.

Authors+Show Affiliations

Department of Medicine, College of Medicine, King Saud University, Abha Branch, Asir Central Hospital, Kingdom of Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8854166

Citation

Tallab, T M., et al. "Cutaneous Leishmaniasis: Schedules for Intralesional Treatment With Sodium Stibogluconate." International Journal of Dermatology, vol. 35, no. 8, 1996, pp. 594-7.
Tallab TM, Bahamdam KA, Mirdad S, et al. Cutaneous leishmaniasis: schedules for intralesional treatment with sodium stibogluconate. Int J Dermatol. 1996;35(8):594-7.
Tallab, T. M., Bahamdam, K. A., Mirdad, S., Johargi, H., Mourad, M. M., Ibrahim, K., el Sherbini, A. H., Karkashan, E., Khare, A. K., & Jamal, A. (1996). Cutaneous leishmaniasis: schedules for intralesional treatment with sodium stibogluconate. International Journal of Dermatology, 35(8), 594-7.
Tallab TM, et al. Cutaneous Leishmaniasis: Schedules for Intralesional Treatment With Sodium Stibogluconate. Int J Dermatol. 1996;35(8):594-7. PubMed PMID: 8854166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous leishmaniasis: schedules for intralesional treatment with sodium stibogluconate. AU - Tallab,T M, AU - Bahamdam,K A, AU - Mirdad,S, AU - Johargi,H, AU - Mourad,M M, AU - Ibrahim,K, AU - el Sherbini,A H, AU - Karkashan,E, AU - Khare,A K, AU - Jamal,A, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 594 EP - 7 JF - International journal of dermatology JO - Int J Dermatol VL - 35 IS - 8 N2 - BACKGROUND: Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been investigated. METHODS: Ninety-six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule. RESULTS: The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate-day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%. CONCLUSIONS: Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/8854166/Cutaneous_leishmaniasis:_schedules_for_intralesional_treatment_with_sodium_stibogluconate_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=1996&volume=35&issue=8&spage=594 DB - PRIME DP - Unbound Medicine ER -