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Vasectomy and prostate cancer: a case-control study in a health maintenance organization.
Am J Epidemiol 1996; 144(8):717-22AJ

Abstract

A case-control study was conducted within Group Health Cooperative of Puget Sound to evaluate the relation between prior vasectomy and the risk of prostate cancer. Cases consisted of 175 men newly diagnosed with histologically confirmed prostate cancer during 1989-1991. A total of 258 controls, matched to cases on birth year and membership status, were randomly selected from the general membership of the plan. Information was collected from mailed questionnaires and medical records on medical history, including prior vasectomy, anthropometric measures, family history of prostate cancer, personal habits, and medical care utilization, and demographic factors. Conditional logistic regression analyses showed that the odds ratio for prostate cancer associated with vasectomy was 0.86 (95% confidence interval 0.57-1.32) after adjustment for confounders. The odds ratio estimate did not differ substantially by age at vasectomy or time since vasectomy. However, the odds ratio estimate for prostate cancer associated with vasectomy tended to be increased among men who had a father or brother with prostate cancer. Nevertheless, the increased risk may be related to detection bias or differential participation rates due to both vasectomy status and a family history of prostate cancer. These results suggest no overall association between vasectomy and prostate cancer.

Authors+Show Affiliations

Department of Epidemiology, University of Washington, Seattle, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8857819

Citation

Zhu, K, et al. "Vasectomy and Prostate Cancer: a Case-control Study in a Health Maintenance Organization." American Journal of Epidemiology, vol. 144, no. 8, 1996, pp. 717-22.
Zhu K, Stanford JL, Daling JR, et al. Vasectomy and prostate cancer: a case-control study in a health maintenance organization. Am J Epidemiol. 1996;144(8):717-22.
Zhu, K., Stanford, J. L., Daling, J. R., McKnight, B., Stergachis, A., Brawer, M. K., & Weiss, N. S. (1996). Vasectomy and prostate cancer: a case-control study in a health maintenance organization. American Journal of Epidemiology, 144(8), pp. 717-22.
Zhu K, et al. Vasectomy and Prostate Cancer: a Case-control Study in a Health Maintenance Organization. Am J Epidemiol. 1996 Oct 15;144(8):717-22. PubMed PMID: 8857819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasectomy and prostate cancer: a case-control study in a health maintenance organization. AU - Zhu,K, AU - Stanford,J L, AU - Daling,J R, AU - McKnight,B, AU - Stergachis,A, AU - Brawer,M K, AU - Weiss,N S, PY - 1996/10/15/pubmed PY - 1996/10/15/medline PY - 1996/10/15/entrez KW - Americas KW - Biology KW - Cancer--determinants KW - Cancer--men KW - Case Control Studies KW - Developed Countries KW - Diseases KW - Family Planning KW - Genitalia KW - Genitalia, Male KW - Male Sterilization KW - Neoplasms KW - North America KW - Northern America KW - Physiology KW - Prostate KW - Research Methodology KW - Research Report KW - Sterilization, Sexual KW - Studies KW - United States KW - Urogenital System KW - Vasectomy KW - Washington SP - 717 EP - 22 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 144 IS - 8 N2 - A case-control study was conducted within Group Health Cooperative of Puget Sound to evaluate the relation between prior vasectomy and the risk of prostate cancer. Cases consisted of 175 men newly diagnosed with histologically confirmed prostate cancer during 1989-1991. A total of 258 controls, matched to cases on birth year and membership status, were randomly selected from the general membership of the plan. Information was collected from mailed questionnaires and medical records on medical history, including prior vasectomy, anthropometric measures, family history of prostate cancer, personal habits, and medical care utilization, and demographic factors. Conditional logistic regression analyses showed that the odds ratio for prostate cancer associated with vasectomy was 0.86 (95% confidence interval 0.57-1.32) after adjustment for confounders. The odds ratio estimate did not differ substantially by age at vasectomy or time since vasectomy. However, the odds ratio estimate for prostate cancer associated with vasectomy tended to be increased among men who had a father or brother with prostate cancer. Nevertheless, the increased risk may be related to detection bias or differential participation rates due to both vasectomy status and a family history of prostate cancer. These results suggest no overall association between vasectomy and prostate cancer. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/8857819/Vasectomy_and_prostate_cancer:_a_case_control_study_in_a_health_maintenance_organization_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a008994 DB - PRIME DP - Unbound Medicine ER -