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Effects of pentoxifylline and nitroprusside on guinea pig cochlear blood flow in relationship to various hematocrit values.
Eur Arch Otorhinolaryngol. 1996; 253(6):345-50.EA

Abstract

To understand better the microcirculation in the inner ear in relation to blood viscosity, we examined the effects of pentoxifylline (PXF) and nitroprusside (NP) on cochlear blood flow (CBF) in healthy adult guinea pigs in relationship to various hematocrit (H1) values. There was no correlation between Ht value and the maximum decrease of mean blood pressure after PXF infusion, whereas there was a positive correlation between Ht and the maximum increase in CBF. No such relationship was found after NP infusion. A graph plot of each animal's blood oxygen transport capacity (i.e., Ht/blood viscosity) was found to have a convex form and to increase with a shift of the peak to a higher Ht area after PXF infusion. These findings indicate that a decrease in blood viscosity may improve CBF and increase oxygen transport capacity of blood.

Authors+Show Affiliations

Ohinata Y
Department of Otolaryngology, Saiseikai Nakatsu Hospital, Osaka, Japan.
Makimoto K
No affiliation info available
Takahashi H
No affiliation info available

MeSH

AnimalsBlood ViscosityCochleaGuinea PigsHematocritMicrocirculationNitroprussideOxygenPentoxifyllineRegional Blood FlowVasodilator Agents

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8858259

Citation

Ohinata, Y, et al. "Effects of Pentoxifylline and Nitroprusside On Guinea Pig Cochlear Blood Flow in Relationship to Various Hematocrit Values." European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, vol. 253, no. 6, 1996, pp. 345-50.
Ohinata Y, Makimoto K, Takahashi H. Effects of pentoxifylline and nitroprusside on guinea pig cochlear blood flow in relationship to various hematocrit values. Eur Arch Otorhinolaryngol. 1996;253(6):345-50.
Ohinata, Y., Makimoto, K., & Takahashi, H. (1996). Effects of pentoxifylline and nitroprusside on guinea pig cochlear blood flow in relationship to various hematocrit values. European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 253(6), 345-50.
Ohinata Y, Makimoto K, Takahashi H. Effects of Pentoxifylline and Nitroprusside On Guinea Pig Cochlear Blood Flow in Relationship to Various Hematocrit Values. Eur Arch Otorhinolaryngol. 1996;253(6):345-50. PubMed PMID: 8858259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of pentoxifylline and nitroprusside on guinea pig cochlear blood flow in relationship to various hematocrit values. AU - Ohinata,Y, AU - Makimoto,K, AU - Takahashi,H, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 345 EP - 50 JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JO - Eur Arch Otorhinolaryngol VL - 253 IS - 6 N2 - To understand better the microcirculation in the inner ear in relation to blood viscosity, we examined the effects of pentoxifylline (PXF) and nitroprusside (NP) on cochlear blood flow (CBF) in healthy adult guinea pigs in relationship to various hematocrit (H1) values. There was no correlation between Ht value and the maximum decrease of mean blood pressure after PXF infusion, whereas there was a positive correlation between Ht and the maximum increase in CBF. No such relationship was found after NP infusion. A graph plot of each animal's blood oxygen transport capacity (i.e., Ht/blood viscosity) was found to have a convex form and to increase with a shift of the peak to a higher Ht area after PXF infusion. These findings indicate that a decrease in blood viscosity may improve CBF and increase oxygen transport capacity of blood. SN - 0937-4477 UR - https://www.unboundmedicine.com/medline/citation/8858259/Effects_of_pentoxifylline_and_nitroprusside_on_guinea_pig_cochlear_blood_flow_in_relationship_to_various_hematocrit_values_ DB - PRIME DP - Unbound Medicine ER -