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Effect of 6 month supplementation with different combinations of an association of antioxidant nutrients on biochemical parameters and markers of the antioxidant defence system in the elderly. The Geriatrie/Min.Vit.Aox Network.

Abstract

OBJECTIVES

To study the effect of supplementation with an association of small physiological amounts of antioxidant nutrients upon biochemical parameters and indicators of oxidative stress and antioxidant enzymes.

DESIGN

The study included a double-blind placebo-controlled design.

SETTING

Nursing homes in different areas in France.

SUBJECTS

575 elderly long term hospitalized subjects aged 65-103 years.

INTERVENTION

Four groups were compared. They received daily: (V) vitamins (vitamin E, 15 mg and vitamin C, 120 mg) and beta-carotene, 6 mg; (T) trace elements (zinc, 20 mg, selenium, 100 micrograms); (VT) vitamins associated with trace elements; or (P) a placebo. Biological markers of vitamin and trace element status, and free radical parameters were measured initially and after 6 months of supplementation.

RESULTS

An analysis of variance indicated a significant effect of vitamin supplementation on serum alpha-tocopherol, beta-carotene and vitamin C, a significant effect of trace element supplementation on serum zinc and both a significant trace element and a vitamin-trace element interaction on serum selenium. We observed significant effects of both trace element and vitamin supplementation on GPx activity (P < 0.01), an effect of vitamin supplementation on SOD activity (P < 0.05).

CONCLUSION

Our results indicate that short-term supplementation with moderate doses of antioxidant vitamins and trace elements in elderly subjects clearly improves both non-enzymatic (alpha-tocopherol, beta-carotene, vitamin C) levels and enzymatic antioxidant (GPx and SOD) activity.

Authors+Show Affiliations

,

Institut Scientifique et Technique de la Nutrition et de l' Alimentation, CNAM, Paris, France.

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Source

MeSH

Aged
Aged, 80 and over
Analysis of Variance
Antioxidants
Chromatography, High Pressure Liquid
Double-Blind Method
Female
Food, Fortified
Health Status
Humans
Lipid Peroxides
Long-Term Care
Male
Nursing Homes
Trace Elements
Vitamins

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8862480

Citation

Monget, A L., et al. "Effect of 6 Month Supplementation With Different Combinations of an Association of Antioxidant Nutrients On Biochemical Parameters and Markers of the Antioxidant Defence System in the Elderly. the Geriatrie/Min.Vit.Aox Network." European Journal of Clinical Nutrition, vol. 50, no. 7, 1996, pp. 443-9.
Monget AL, Richard MJ, Cournot MP, et al. Effect of 6 month supplementation with different combinations of an association of antioxidant nutrients on biochemical parameters and markers of the antioxidant defence system in the elderly. The Geriatrie/Min.Vit.Aox Network. Eur J Clin Nutr. 1996;50(7):443-9.
Monget, A. L., Richard, M. J., Cournot, M. P., Arnaud, J., Galan, P., Preziosi, P., ... Hercberg, S. (1996). Effect of 6 month supplementation with different combinations of an association of antioxidant nutrients on biochemical parameters and markers of the antioxidant defence system in the elderly. The Geriatrie/Min.Vit.Aox Network. European Journal of Clinical Nutrition, 50(7), pp. 443-9.
Monget AL, et al. Effect of 6 Month Supplementation With Different Combinations of an Association of Antioxidant Nutrients On Biochemical Parameters and Markers of the Antioxidant Defence System in the Elderly. the Geriatrie/Min.Vit.Aox Network. Eur J Clin Nutr. 1996;50(7):443-9. PubMed PMID: 8862480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of 6 month supplementation with different combinations of an association of antioxidant nutrients on biochemical parameters and markers of the antioxidant defence system in the elderly. The Geriatrie/Min.Vit.Aox Network. AU - Monget,A L, AU - Richard,M J, AU - Cournot,M P, AU - Arnaud,J, AU - Galan,P, AU - Preziosi,P, AU - Herbeth,B, AU - Favier,A, AU - Hercberg,S, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 443 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 50 IS - 7 N2 - OBJECTIVES: To study the effect of supplementation with an association of small physiological amounts of antioxidant nutrients upon biochemical parameters and indicators of oxidative stress and antioxidant enzymes. DESIGN: The study included a double-blind placebo-controlled design. SETTING: Nursing homes in different areas in France. SUBJECTS: 575 elderly long term hospitalized subjects aged 65-103 years. INTERVENTION: Four groups were compared. They received daily: (V) vitamins (vitamin E, 15 mg and vitamin C, 120 mg) and beta-carotene, 6 mg; (T) trace elements (zinc, 20 mg, selenium, 100 micrograms); (VT) vitamins associated with trace elements; or (P) a placebo. Biological markers of vitamin and trace element status, and free radical parameters were measured initially and after 6 months of supplementation. RESULTS: An analysis of variance indicated a significant effect of vitamin supplementation on serum alpha-tocopherol, beta-carotene and vitamin C, a significant effect of trace element supplementation on serum zinc and both a significant trace element and a vitamin-trace element interaction on serum selenium. We observed significant effects of both trace element and vitamin supplementation on GPx activity (P < 0.01), an effect of vitamin supplementation on SOD activity (P < 0.05). CONCLUSION: Our results indicate that short-term supplementation with moderate doses of antioxidant vitamins and trace elements in elderly subjects clearly improves both non-enzymatic (alpha-tocopherol, beta-carotene, vitamin C) levels and enzymatic antioxidant (GPx and SOD) activity. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/8862480/Effect_of_6_month_supplementation_with_different_combinations_of_an_association_of_antioxidant_nutrients_on_biochemical_parameters_and_markers_of_the_antioxidant_defence_system_in_the_elderly__The_Geriatrie/Min_Vit_Aox_Network_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -