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Drinking water nitrate and the risk of non-Hodgkin's lymphoma.

Abstract

The increasing incidence of non-Hodgkin's lymphoma (NHL) in the United States is only partially explained by known risk factors. Nitrate is a contaminant of drinking water in many rural areas. We evaluated its association with NHL after accounting for dietary nitrate intake. For 156 cases and 527 controls who used Nebraska community supplies, average nitrate exposure was estimated from 1947 through 1979. Longterm consumption of community water with average nitrate levels in the highest quartile (> or = 4 mg per liter nitrate-nitrogen) was positively associated with risk [odds ratio (OR) = 2.0; 95% confidence interval (CI) = 1.1-3.6]. Dietary nitrate, which came mainly from vegetables, was not associated with NHL risk, after adjusting for vitamin C and carotene intakes. Persons with a lower intake of vitamin C were at slightly higher risk of developing NHL than persons whose daily intake was > or = 130 mg, for all levels of intake of drinking water nitrate; our findings were similar for the combined effect of water nitrate and carotene intake. Nitrate levels in private wells were measured at the time of the interview for 51 cases and 150 controls but were not associated with the risk of NHL after adjusting for pesticide use on the farm. These findings indicate that longterm exposure to elevated nitrate levels in drinking water may contribute to the risk of NHL.

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  • Authors+Show Affiliations

    ,

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7364, USA.

    , , , ,

    Source

    Epidemiology (Cambridge, Mass.) 7:5 1996 Sep pg 465-71

    MeSH

    Adult
    Aged
    Case-Control Studies
    Confidence Intervals
    Diet
    Female
    Humans
    Incidence
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    Nebraska
    Nitrates
    Odds Ratio
    Risk Factors
    Rural Health
    Water Pollutants, Chemical
    Water Supply

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    8862975

    Citation

    Ward, M H., et al. "Drinking Water Nitrate and the Risk of non-Hodgkin's Lymphoma." Epidemiology (Cambridge, Mass.), vol. 7, no. 5, 1996, pp. 465-71.
    Ward MH, Mark SD, Cantor KP, et al. Drinking water nitrate and the risk of non-Hodgkin's lymphoma. Epidemiology. 1996;7(5):465-71.
    Ward, M. H., Mark, S. D., Cantor, K. P., Weisenburger, D. D., Correa-Villaseñor, A., & Zahm, S. H. (1996). Drinking water nitrate and the risk of non-Hodgkin's lymphoma. Epidemiology (Cambridge, Mass.), 7(5), pp. 465-71.
    Ward MH, et al. Drinking Water Nitrate and the Risk of non-Hodgkin's Lymphoma. Epidemiology. 1996;7(5):465-71. PubMed PMID: 8862975.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Drinking water nitrate and the risk of non-Hodgkin's lymphoma. AU - Ward,M H, AU - Mark,S D, AU - Cantor,K P, AU - Weisenburger,D D, AU - Correa-Villaseñor,A, AU - Zahm,S H, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 465 EP - 71 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 7 IS - 5 N2 - The increasing incidence of non-Hodgkin's lymphoma (NHL) in the United States is only partially explained by known risk factors. Nitrate is a contaminant of drinking water in many rural areas. We evaluated its association with NHL after accounting for dietary nitrate intake. For 156 cases and 527 controls who used Nebraska community supplies, average nitrate exposure was estimated from 1947 through 1979. Longterm consumption of community water with average nitrate levels in the highest quartile (> or = 4 mg per liter nitrate-nitrogen) was positively associated with risk [odds ratio (OR) = 2.0; 95% confidence interval (CI) = 1.1-3.6]. Dietary nitrate, which came mainly from vegetables, was not associated with NHL risk, after adjusting for vitamin C and carotene intakes. Persons with a lower intake of vitamin C were at slightly higher risk of developing NHL than persons whose daily intake was > or = 130 mg, for all levels of intake of drinking water nitrate; our findings were similar for the combined effect of water nitrate and carotene intake. Nitrate levels in private wells were measured at the time of the interview for 51 cases and 150 controls but were not associated with the risk of NHL after adjusting for pesticide use on the farm. These findings indicate that longterm exposure to elevated nitrate levels in drinking water may contribute to the risk of NHL. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/8862975/Drinking_water_nitrate_and_the_risk_of_non_Hodgkin's_lymphoma_ L2 - http://Insights.ovid.com/pubmed?pmid=8862975 DB - PRIME DP - Unbound Medicine ER -