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Meal frequency; does it determine postprandial lipaemia?
Eur J Clin Nutr 1996; 50(8):491-7EJ

Abstract

OBJECTIVE

To determine the effect of altering meal frequency on postprandial lipaemia and associated parameters.

DESIGN

A randomized open cross over study to examine the programming effects of altering meal frequency. A standard test meal was given on three occasions following: (i) the normal diet; (ii) a period of two weeks on a nibbling and (iii) a period of two weeks on a gorging diet.

SETTING

Free living subjects associated with the University of Surrey.

SUBJECTS

Eleven female volunteers (age 22 +/- 0.89 y) were recruited.

INTERVENTIONS

The subjects were requested to consume the same foods on either a nibbling diet (12 meals per day) or a gorging diet (three meals per day) for a period of two weeks. The standard test meal containing 80 g fat, 63 g carbohydrate and 20 g protein was administered on the day prior to the dietary intervention and on the day following each period of intervention.

MAJOR OUTCOME MEASURES

Fasting and postprandial blood samples were taken for the analysis of plasma triacylglycerol, non-esterified fatty acids, glucose, immunoreactive insulin, glucose-dependent insulinotropic polypeptide levels (GIP) and glucagon-like peptide (GLP-1), fasting total, low density lipoprotein (LDL)- and high density lipoprotein (HDL)-cholesterol concentrations and postheparin lipoprotein lipase (LPL) activity measurements. Plasma paracetamol was measured following administration of a 1.5 g paracetamol load with the meal as an index of gastric emptying.

RESULTS

The compliance to the two dietary regimes was high and there were no significant differences between the nutrient intakes on the two intervention diets. There were no significant differences in fasting or postprandial plasma concentrations of triacylglycerol, non-esterified fatty acids, glucose, immunoreactive insulin, GIP and GLP-1 levels, in response to the standard test meal following the nibbling or gorging dietary regimes. There were no significant differences in fasting total or LDL-cholesterol concentrations, or in the 15 min postheparin lipoprotein lipase activity measurements. There was a significant increase in HDL-cholesterol in the subjects following the gorging diet compared to the nibbling diet.

DISCUSSION

The results suggest that previous meal frequency for a period of two weeks in young healthy women does not alter the fasting or postprandial lipid or hormonal response to a standard high fat meal.

CONCLUSIONS

The findings of this study did not confirm the previous studies which suggested that nibbling is beneficial in reducing the concentrations of lipid and hormones. The rigorous control of diet content and composition in the present study compared with others, suggest reported effects of meal frequency may be due to unintentional alteration in nutrient and energy intake in previous studies.

Authors+Show Affiliations

Nutrition Research Group, School of Biological Sciences, University of Surrey, Guildford, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8863008

Citation

Murphy, M C., et al. "Meal Frequency; Does It Determine Postprandial Lipaemia?" European Journal of Clinical Nutrition, vol. 50, no. 8, 1996, pp. 491-7.
Murphy MC, Chapman C, Lovegrove JA, et al. Meal frequency; does it determine postprandial lipaemia? Eur J Clin Nutr. 1996;50(8):491-7.
Murphy, M. C., Chapman, C., Lovegrove, J. A., Isherwood, S. G., Morgan, L. M., Wright, J. W., & Williams, C. M. (1996). Meal frequency; does it determine postprandial lipaemia? European Journal of Clinical Nutrition, 50(8), pp. 491-7.
Murphy MC, et al. Meal Frequency; Does It Determine Postprandial Lipaemia. Eur J Clin Nutr. 1996;50(8):491-7. PubMed PMID: 8863008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meal frequency; does it determine postprandial lipaemia? AU - Murphy,M C, AU - Chapman,C, AU - Lovegrove,J A, AU - Isherwood,S G, AU - Morgan,L M, AU - Wright,J W, AU - Williams,C M, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 491 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 50 IS - 8 N2 - OBJECTIVE: To determine the effect of altering meal frequency on postprandial lipaemia and associated parameters. DESIGN: A randomized open cross over study to examine the programming effects of altering meal frequency. A standard test meal was given on three occasions following: (i) the normal diet; (ii) a period of two weeks on a nibbling and (iii) a period of two weeks on a gorging diet. SETTING: Free living subjects associated with the University of Surrey. SUBJECTS: Eleven female volunteers (age 22 +/- 0.89 y) were recruited. INTERVENTIONS: The subjects were requested to consume the same foods on either a nibbling diet (12 meals per day) or a gorging diet (three meals per day) for a period of two weeks. The standard test meal containing 80 g fat, 63 g carbohydrate and 20 g protein was administered on the day prior to the dietary intervention and on the day following each period of intervention. MAJOR OUTCOME MEASURES: Fasting and postprandial blood samples were taken for the analysis of plasma triacylglycerol, non-esterified fatty acids, glucose, immunoreactive insulin, glucose-dependent insulinotropic polypeptide levels (GIP) and glucagon-like peptide (GLP-1), fasting total, low density lipoprotein (LDL)- and high density lipoprotein (HDL)-cholesterol concentrations and postheparin lipoprotein lipase (LPL) activity measurements. Plasma paracetamol was measured following administration of a 1.5 g paracetamol load with the meal as an index of gastric emptying. RESULTS: The compliance to the two dietary regimes was high and there were no significant differences between the nutrient intakes on the two intervention diets. There were no significant differences in fasting or postprandial plasma concentrations of triacylglycerol, non-esterified fatty acids, glucose, immunoreactive insulin, GIP and GLP-1 levels, in response to the standard test meal following the nibbling or gorging dietary regimes. There were no significant differences in fasting total or LDL-cholesterol concentrations, or in the 15 min postheparin lipoprotein lipase activity measurements. There was a significant increase in HDL-cholesterol in the subjects following the gorging diet compared to the nibbling diet. DISCUSSION: The results suggest that previous meal frequency for a period of two weeks in young healthy women does not alter the fasting or postprandial lipid or hormonal response to a standard high fat meal. CONCLUSIONS: The findings of this study did not confirm the previous studies which suggested that nibbling is beneficial in reducing the concentrations of lipid and hormones. The rigorous control of diet content and composition in the present study compared with others, suggest reported effects of meal frequency may be due to unintentional alteration in nutrient and energy intake in previous studies. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/8863008/Meal_frequency DB - PRIME DP - Unbound Medicine ER -