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Gastro-oesophageal reflux disease in The Netherlands. Results of a multicentre pH study.

Abstract

Information on the relationships between gastro-oesophageal reflux (GOR), reflux symptoms, hiatal hernia (HH) and oesophagitis, and the response to antisecretory treatment is lacking. In a multicentre study endoscopy, ambulatory 24-h pH monitoring and symptom assessment were carried out in 142 patients with symptomatic reflux disease before and during treatment with ranitidine. Using a randomized, double-blind design, patients took ranitidine 150 mg bid or 300 mg bid. Macroscopic oesophagitis (grade I or II) was found in 85 patients; the remaining 57 patients had normal oesophageal mucosa. A significant correlation was found between the presence of an HH and the presence of oesophagitis. Symptom scores were similar in patients with and without oesophagitis, and in patients with and without HH. Patients with oesophagitis had significantly greater oesophageal acid exposure during the night, and in the total 24-h period, but not during the day. Likewise, patients with HH had greater acid exposure during the night (p < 0.008). Both doses of ranitidine significantly decreased oesophageal acid exposure and the effect was independent of baseline acid exposure. Reflux symptoms cannot be used to differentiate between presence or absence of oesophagitis and/or HH. Reflux patients without oesophagitis have less night-time reflux. Ranitidine dose-dependently decreases oesophageal acid exposure, and the effect is independent of baseline reflux.

Authors+Show Affiliations

Dept. of Gastroenterology, University Hospital Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

8865445

Citation

Smout, A J., et al. "Gastro-oesophageal Reflux Disease in the Netherlands. Results of a Multicentre pH Study." Scandinavian Journal of Gastroenterology. Supplement, vol. 218, 1996, pp. 10-5.
Smout AJ, Geus WP, Mulder PG, et al. Gastro-oesophageal reflux disease in The Netherlands. Results of a multicentre pH study. Scand J Gastroenterol Suppl. 1996;218:10-5.
Smout, A. J., Geus, W. P., Mulder, P. G., Stockbrügger, R. W., & Lamers, C. B. (1996). Gastro-oesophageal reflux disease in The Netherlands. Results of a multicentre pH study. Scandinavian Journal of Gastroenterology. Supplement, 218, pp. 10-5.
Smout AJ, et al. Gastro-oesophageal Reflux Disease in the Netherlands. Results of a Multicentre pH Study. Scand J Gastroenterol Suppl. 1996;218:10-5. PubMed PMID: 8865445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastro-oesophageal reflux disease in The Netherlands. Results of a multicentre pH study. AU - Smout,A J, AU - Geus,W P, AU - Mulder,P G, AU - Stockbrügger,R W, AU - Lamers,C B, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 10 EP - 5 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand. J. Gastroenterol. Suppl. VL - 218 N2 - Information on the relationships between gastro-oesophageal reflux (GOR), reflux symptoms, hiatal hernia (HH) and oesophagitis, and the response to antisecretory treatment is lacking. In a multicentre study endoscopy, ambulatory 24-h pH monitoring and symptom assessment were carried out in 142 patients with symptomatic reflux disease before and during treatment with ranitidine. Using a randomized, double-blind design, patients took ranitidine 150 mg bid or 300 mg bid. Macroscopic oesophagitis (grade I or II) was found in 85 patients; the remaining 57 patients had normal oesophageal mucosa. A significant correlation was found between the presence of an HH and the presence of oesophagitis. Symptom scores were similar in patients with and without oesophagitis, and in patients with and without HH. Patients with oesophagitis had significantly greater oesophageal acid exposure during the night, and in the total 24-h period, but not during the day. Likewise, patients with HH had greater acid exposure during the night (p < 0.008). Both doses of ranitidine significantly decreased oesophageal acid exposure and the effect was independent of baseline acid exposure. Reflux symptoms cannot be used to differentiate between presence or absence of oesophagitis and/or HH. Reflux patients without oesophagitis have less night-time reflux. Ranitidine dose-dependently decreases oesophageal acid exposure, and the effect is independent of baseline reflux. SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/8865445/Gastro_oesophageal_reflux_disease_in_The_Netherlands__Results_of_a_multicentre_pH_study_ L2 - https://medlineplus.gov/gerd.html DB - PRIME DP - Unbound Medicine ER -