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Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria.
Dementia 1996 Mar-Apr; 7(2):76-81D

Abstract

Neurofibrillary tangles (NFT), neuritic plaques and amyloid load were quantified in sections of the hippocampus at the level of the lateral geniculate body in 41 consecutive cases fulfilling pathological criteria for diagnosis of Alzheimer's disease (AD) and coming to autopsy after longitudinal study during life. A strong correlation was found between NFT density in the hippocampus and cognitive impairment scores obtained shortly before death, particularly with scores of memory impairment. Weaker and less consistent correlations were found for hippocampal neuritic plaques and amyloid load with cognitive/memory deficits. No significant correlations were found between hippocampal pathology and either age of onset or disease duration. All three measures of hippocampal pathology were inversely correlated with the minimum medial temporal lobe (MTL) width, a measure of the MTL atrophy made from temporal-lobe-oriented X-ray computed tomography scans performed during life; the strongest correlation being between atrophy of the MTL and NFT density in the hippocampus.

Authors+Show Affiliations

Department of Neuropathology, University of Oxford, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8866679

Citation

Nagy, Z, et al. "Hippocampal Pathology Reflects Memory Deficit and Brain Imaging Measurements in Alzheimer's Disease: Clinicopathologic Correlations Using Three Sets of Pathologic Diagnostic Criteria." Dementia (Basel, Switzerland), vol. 7, no. 2, 1996, pp. 76-81.
Nagy Z, Jobst KA, Esiri MM, et al. Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. Dementia. 1996;7(2):76-81.
Nagy, Z., Jobst, K. A., Esiri, M. M., Morris, J. H., King, E. M., MacDonald, B., ... Smith, A. D. (1996). Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. Dementia (Basel, Switzerland), 7(2), pp. 76-81.
Nagy Z, et al. Hippocampal Pathology Reflects Memory Deficit and Brain Imaging Measurements in Alzheimer's Disease: Clinicopathologic Correlations Using Three Sets of Pathologic Diagnostic Criteria. Dementia. 1996;7(2):76-81. PubMed PMID: 8866679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. AU - Nagy,Z, AU - Jobst,K A, AU - Esiri,M M, AU - Morris,J H, AU - King,E M, AU - MacDonald,B, AU - Litchfield,S, AU - Barnetson,L, AU - Smith,A D, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 76 EP - 81 JF - Dementia (Basel, Switzerland) JO - Dementia VL - 7 IS - 2 N2 - Neurofibrillary tangles (NFT), neuritic plaques and amyloid load were quantified in sections of the hippocampus at the level of the lateral geniculate body in 41 consecutive cases fulfilling pathological criteria for diagnosis of Alzheimer's disease (AD) and coming to autopsy after longitudinal study during life. A strong correlation was found between NFT density in the hippocampus and cognitive impairment scores obtained shortly before death, particularly with scores of memory impairment. Weaker and less consistent correlations were found for hippocampal neuritic plaques and amyloid load with cognitive/memory deficits. No significant correlations were found between hippocampal pathology and either age of onset or disease duration. All three measures of hippocampal pathology were inversely correlated with the minimum medial temporal lobe (MTL) width, a measure of the MTL atrophy made from temporal-lobe-oriented X-ray computed tomography scans performed during life; the strongest correlation being between atrophy of the MTL and NFT density in the hippocampus. SN - 1013-7424 UR - https://www.unboundmedicine.com/medline/citation/8866679/Hippocampal_pathology_reflects_memory_deficit_and_brain_imaging_measurements_in_Alzheimer's_disease:_clinicopathologic_correlations_using_three_sets_of_pathologic_diagnostic_criteria_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -