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Anti-inflammatory and radical scavenge effects of Arctium lappa.
Am J Chin Med. 1996; 24(2):127-37.AJ

Abstract

The effects of Arctium lappa L. (root) on anti-inflammatory and free radical scavenger activity were investigated. Subcutaneous administration of A. lappa crude extract significantly decreased carrageenan-induced rat paw edema. When simultaneously treated with CCl4, it produced pronounced activities against CCl4-induced acute liver damage. The free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (ESR) spectrometer. The IC50 of A. lappa extract on superoxide and hydroxyl radical scavenger activity was 2.06 mg/ml and 11.8 mg/ml, respectively. These findings suggest that Arctium lappa possess free radical scavenging activity. The inhibitory effects on carrageenan-induced paw edema and CCl4-induced hepatotoxicity could be due to the scavenging effect of A. lappa.

Authors+Show Affiliations

Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8874669

Citation

Lin, C C., et al. "Anti-inflammatory and Radical Scavenge Effects of Arctium Lappa." The American Journal of Chinese Medicine, vol. 24, no. 2, 1996, pp. 127-37.
Lin CC, Lu JM, Yang JJ, et al. Anti-inflammatory and radical scavenge effects of Arctium lappa. Am J Chin Med. 1996;24(2):127-37.
Lin, C. C., Lu, J. M., Yang, J. J., Chuang, S. C., & Ujiie, T. (1996). Anti-inflammatory and radical scavenge effects of Arctium lappa. The American Journal of Chinese Medicine, 24(2), 127-37.
Lin CC, et al. Anti-inflammatory and Radical Scavenge Effects of Arctium Lappa. Am J Chin Med. 1996;24(2):127-37. PubMed PMID: 8874669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and radical scavenge effects of Arctium lappa. AU - Lin,C C, AU - Lu,J M, AU - Yang,J J, AU - Chuang,S C, AU - Ujiie,T, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 127 EP - 37 JF - The American journal of Chinese medicine JO - Am J Chin Med VL - 24 IS - 2 N2 - The effects of Arctium lappa L. (root) on anti-inflammatory and free radical scavenger activity were investigated. Subcutaneous administration of A. lappa crude extract significantly decreased carrageenan-induced rat paw edema. When simultaneously treated with CCl4, it produced pronounced activities against CCl4-induced acute liver damage. The free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (ESR) spectrometer. The IC50 of A. lappa extract on superoxide and hydroxyl radical scavenger activity was 2.06 mg/ml and 11.8 mg/ml, respectively. These findings suggest that Arctium lappa possess free radical scavenging activity. The inhibitory effects on carrageenan-induced paw edema and CCl4-induced hepatotoxicity could be due to the scavenging effect of A. lappa. SN - 0192-415X UR - https://www.unboundmedicine.com/medline/citation/8874669/Anti_inflammatory_and_radical_scavenge_effects_of_Arctium_lappa_ L2 - https://www.worldscientific.com/doi/10.1142/S0192415X96000177?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -