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Dietary nitrosodimethylamine and the risk of lung cancer: a case-control study from Uruguay.

Abstract

Evidence from animal studies indicates that various N-nitroso compounds are carcinogenic. We investigated whether consumption of nitrosodimethylamine (NDMA) and foods and beverages containing NDMA are carcinogenic for the lung. In a hospital-based case-control study in Uruguay, dietary intake of NDMA and its food sources was measured in 320 cases of lung cancer and 320 controls afflicted with diseases not related with tobacco use and diet. After adjusting for tobacco smoking and total energy intake, NDMA displayed a significant dose-response pattern, with a 3-fold increase in risk for the higher category of intake. The risks were slightly more elevated for adenocarcinoma of the lung. Also, salted meat consumption and beer intake were associated with an increased risk of lung cancer.

Authors+Show Affiliations

Registro Nacional de Cancer, Instituto Nacional de Oncologia, Montevideo, Uruguay.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8877057

Citation

De Stefani, E, et al. "Dietary Nitrosodimethylamine and the Risk of Lung Cancer: a Case-control Study From Uruguay." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 5, no. 9, 1996, pp. 679-82.
De Stefani E, Deneo-Pellegrini H, Carzoglio JC, et al. Dietary nitrosodimethylamine and the risk of lung cancer: a case-control study from Uruguay. Cancer Epidemiol Biomarkers Prev. 1996;5(9):679-82.
De Stefani, E., Deneo-Pellegrini, H., Carzoglio, J. C., Ronco, A., & Mendilaharsu, M. (1996). Dietary nitrosodimethylamine and the risk of lung cancer: a case-control study from Uruguay. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 5(9), pp. 679-82.
De Stefani E, et al. Dietary Nitrosodimethylamine and the Risk of Lung Cancer: a Case-control Study From Uruguay. Cancer Epidemiol Biomarkers Prev. 1996;5(9):679-82. PubMed PMID: 8877057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary nitrosodimethylamine and the risk of lung cancer: a case-control study from Uruguay. AU - De Stefani,E, AU - Deneo-Pellegrini,H, AU - Carzoglio,J C, AU - Ronco,A, AU - Mendilaharsu,M, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 679 EP - 82 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 5 IS - 9 N2 - Evidence from animal studies indicates that various N-nitroso compounds are carcinogenic. We investigated whether consumption of nitrosodimethylamine (NDMA) and foods and beverages containing NDMA are carcinogenic for the lung. In a hospital-based case-control study in Uruguay, dietary intake of NDMA and its food sources was measured in 320 cases of lung cancer and 320 controls afflicted with diseases not related with tobacco use and diet. After adjusting for tobacco smoking and total energy intake, NDMA displayed a significant dose-response pattern, with a 3-fold increase in risk for the higher category of intake. The risks were slightly more elevated for adenocarcinoma of the lung. Also, salted meat consumption and beer intake were associated with an increased risk of lung cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/8877057/Dietary_nitrosodimethylamine_and_the_risk_of_lung_cancer:_a_case_control_study_from_Uruguay_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8877057 DB - PRIME DP - Unbound Medicine ER -