TY - JOUR T1 - Genetics of osteoarthritis. AU - Cicuttini,F M, AU - Spector,T D, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 665 EP - 7 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 55 IS - 9 N2 - The available evidence suggests that genetic factors have a major role in osteoarthritis. It has been believed for over 50 years that a strong genetic component to certain forms of osteoarthritis is present. This genetic influence has now been estimated to be up to 65% in a recent twin study. The nature of the genetic influence in osteoarthritis is speculative and may involve either a structural defect (that is, collagen), alterations in cartilage or bone metabolism, or alternatively a genetic influence on a known risk factor for osteoarthritis such as obesity. Exciting work has showed that mutations in the collagen type 2 are important in some rare, familial forms of osteoarthritis. Further work is needed on isolating the gene or genes involved in the pathogenesis of this common, disabling condition. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/8882145/Genetics_of_osteoarthritis_ L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&pmid=8882145 DB - PRIME DP - Unbound Medicine ER -