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Postprandial activation of coagulant factor VII by long-chain dietary fatty acids.
Thromb Haemost. 1996 Sep; 76(3):369-71.TH

Abstract

Factor VII coagulant activity (FVIIc) is associated with an increased risk of fatal ischaemic heart disease (IHD). Several reports have suggested that dietary fat intake or hypertriglyceridaemia are associated with elevated levels of FVII. This study demonstrates that an intake of long-chain fatty acids sufficient to induce postprandial lipaemia in healthy subjects leads to a substantial elevation in both FVIIc and the concentration of FVII circulating in the activated form. Such an increase in FVIIc could not be induced by medium-chain triglycerides. These results suggest that the consumption of a sufficient amount of long-chain triglycerides to induce postprandial lipaemia induces the activation of FVII.

Authors+Show Affiliations

Nutrition, Food and Health Research Centre, King's College, University of London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8883272

Citation

Sanders, T A., et al. "Postprandial Activation of Coagulant Factor VII By Long-chain Dietary Fatty Acids." Thrombosis and Haemostasis, vol. 76, no. 3, 1996, pp. 369-71.
Sanders TA, Miller GJ, de Grass T, et al. Postprandial activation of coagulant factor VII by long-chain dietary fatty acids. Thromb Haemost. 1996;76(3):369-71.
Sanders, T. A., Miller, G. J., de Grass, T., & Yahia, N. (1996). Postprandial activation of coagulant factor VII by long-chain dietary fatty acids. Thrombosis and Haemostasis, 76(3), 369-71.
Sanders TA, et al. Postprandial Activation of Coagulant Factor VII By Long-chain Dietary Fatty Acids. Thromb Haemost. 1996;76(3):369-71. PubMed PMID: 8883272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial activation of coagulant factor VII by long-chain dietary fatty acids. AU - Sanders,T A, AU - Miller,G J, AU - de Grass,T, AU - Yahia,N, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 369 EP - 71 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 76 IS - 3 N2 - Factor VII coagulant activity (FVIIc) is associated with an increased risk of fatal ischaemic heart disease (IHD). Several reports have suggested that dietary fat intake or hypertriglyceridaemia are associated with elevated levels of FVII. This study demonstrates that an intake of long-chain fatty acids sufficient to induce postprandial lipaemia in healthy subjects leads to a substantial elevation in both FVIIc and the concentration of FVII circulating in the activated form. Such an increase in FVIIc could not be induced by medium-chain triglycerides. These results suggest that the consumption of a sufficient amount of long-chain triglycerides to induce postprandial lipaemia induces the activation of FVII. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/8883272/Postprandial_activation_of_coagulant_factor_VII_by_long_chain_dietary_fatty_acids_ DB - PRIME DP - Unbound Medicine ER -