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A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy.
Exp Clin Endocrinol Diabetes. 1996; 104(4):311-6.EC

Abstract

In a double-blind, randomized, controlled study, the effectiveness of treatment with a combination of Benfotiamine (an Allithiamine, a lipid-soluble derivative of vitamin B1 with high bioavailability) plus vitamin B6/B12 on objective parameters of neuropathy was studied over a period of 12 weeks on 24 diabetic patients with diabetic polyneuropathy. The results showed a significant improvement (p = 0.006) of nerve conduction velocity in the peroneal nerve and a statistical trend toward improvement of the vibration perception threshold. Long-term observation of 9 patients with verum over a period of 9 months support the results. Therapy-specific adverse effects were not seen. The results of this double-blind investigation, of the long-term observation and of the reports in the literature support the contention that the neurotropic benfotiamine-vitamin B combination represents a starting point in the treatment of diabetic polyneuropathy.

Authors+Show Affiliations

Third Medical Department, University of Giessen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8886748

Citation

Stracke, H, et al. "A Benfotiamine-vitamin B Combination in Treatment of Diabetic Polyneuropathy." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 104, no. 4, 1996, pp. 311-6.
Stracke H, Lindemann A, Federlin K. A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.
Stracke, H., Lindemann, A., & Federlin, K. (1996). A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 104(4), 311-6.
Stracke H, Lindemann A, Federlin K. A Benfotiamine-vitamin B Combination in Treatment of Diabetic Polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6. PubMed PMID: 8886748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. AU - Stracke,H, AU - Lindemann,A, AU - Federlin,K, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 311 EP - 6 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp Clin Endocrinol Diabetes VL - 104 IS - 4 N2 - In a double-blind, randomized, controlled study, the effectiveness of treatment with a combination of Benfotiamine (an Allithiamine, a lipid-soluble derivative of vitamin B1 with high bioavailability) plus vitamin B6/B12 on objective parameters of neuropathy was studied over a period of 12 weeks on 24 diabetic patients with diabetic polyneuropathy. The results showed a significant improvement (p = 0.006) of nerve conduction velocity in the peroneal nerve and a statistical trend toward improvement of the vibration perception threshold. Long-term observation of 9 patients with verum over a period of 9 months support the results. Therapy-specific adverse effects were not seen. The results of this double-blind investigation, of the long-term observation and of the reports in the literature support the contention that the neurotropic benfotiamine-vitamin B combination represents a starting point in the treatment of diabetic polyneuropathy. SN - 0947-7349 UR - https://www.unboundmedicine.com/medline/citation/8886748/A_benfotiamine_vitamin_B_combination_in_treatment_of_diabetic_polyneuropathy_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1211460 DB - PRIME DP - Unbound Medicine ER -