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Delta-aminolevulinic acid dehydratase and zinc protoporphyrin in very low lead-exposed pets: a community study.
Vet Hum Toxicol. 1996 Oct; 38(5):336-9.VH

Abstract

Markers of lead intoxication have been developed based on their capacity to identify lead intoxication at the preclinical, ie biochemical stage of manifestation. However, little information on these markers is available under conditions of low lead exposure. This prompted us to conduct a community-based study to determine the usefulness of theta-aminolevulinic acid dehydratase (ALAD) and zinc protoporphyrin (ZnPP) in conditions of low lead environmental exposure by studying the relationships between low blood lead levels, ALAD and ZnPP in a large group of healthy dogs living in an Italian urban area. The study population consisted of 79 dogs. Each sample was tested for ALAD, lead and ZnPP and for complete blood count, hemoglobin, AST, ALT, and urea values. A weak inverse relationship between ALAD and ZnPP was found. An inverse relationship between ALAD and lead concentrations was found in the whole group (p < 0.0005). This relationship remained significant when selecting the values falling between 2 standard deviations of the mean blood lead concentrations of the population below the "concerned lead levels" (< 10 mg/dl; p = 0.0005). There was no relationship between whole blood ZnPP concentrations and whole blood lead levels. The sensitivity and specificity of ALAD measurements, calculated by using the 2 x 2 contingency table with respect to blood lead concentrations, were of poor predictive diagnostic value.

Authors+Show Affiliations

Institute of Veterinary Clinical Medicine, Faculty of Veterinary Medicine, Pisa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8888535

Citation

Ambrogi, C, et al. "Delta-aminolevulinic Acid Dehydratase and Zinc Protoporphyrin in Very Low Lead-exposed Pets: a Community Study." Veterinary and Human Toxicology, vol. 38, no. 5, 1996, pp. 336-9.
Ambrogi C, Cardini G, Baldi SB, et al. Delta-aminolevulinic acid dehydratase and zinc protoporphyrin in very low lead-exposed pets: a community study. Vet Hum Toxicol. 1996;38(5):336-9.
Ambrogi, C., Cardini, G., Baldi, S. B., Cini, C. C., Buzzigoli, G., Quinones-Galvan, A., & Ferrannini, E. (1996). Delta-aminolevulinic acid dehydratase and zinc protoporphyrin in very low lead-exposed pets: a community study. Veterinary and Human Toxicology, 38(5), 336-9.
Ambrogi C, et al. Delta-aminolevulinic Acid Dehydratase and Zinc Protoporphyrin in Very Low Lead-exposed Pets: a Community Study. Vet Hum Toxicol. 1996;38(5):336-9. PubMed PMID: 8888535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta-aminolevulinic acid dehydratase and zinc protoporphyrin in very low lead-exposed pets: a community study. AU - Ambrogi,C, AU - Cardini,G, AU - Baldi,S B, AU - Cini,C C, AU - Buzzigoli,G, AU - Quinones-Galvan,A, AU - Ferrannini,E, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 336 EP - 9 JF - Veterinary and human toxicology JO - Vet Hum Toxicol VL - 38 IS - 5 N2 - Markers of lead intoxication have been developed based on their capacity to identify lead intoxication at the preclinical, ie biochemical stage of manifestation. However, little information on these markers is available under conditions of low lead exposure. This prompted us to conduct a community-based study to determine the usefulness of theta-aminolevulinic acid dehydratase (ALAD) and zinc protoporphyrin (ZnPP) in conditions of low lead environmental exposure by studying the relationships between low blood lead levels, ALAD and ZnPP in a large group of healthy dogs living in an Italian urban area. The study population consisted of 79 dogs. Each sample was tested for ALAD, lead and ZnPP and for complete blood count, hemoglobin, AST, ALT, and urea values. A weak inverse relationship between ALAD and ZnPP was found. An inverse relationship between ALAD and lead concentrations was found in the whole group (p < 0.0005). This relationship remained significant when selecting the values falling between 2 standard deviations of the mean blood lead concentrations of the population below the "concerned lead levels" (< 10 mg/dl; p = 0.0005). There was no relationship between whole blood ZnPP concentrations and whole blood lead levels. The sensitivity and specificity of ALAD measurements, calculated by using the 2 x 2 contingency table with respect to blood lead concentrations, were of poor predictive diagnostic value. SN - 0145-6296 UR - https://www.unboundmedicine.com/medline/citation/8888535/Delta_aminolevulinic_acid_dehydratase_and_zinc_protoporphyrin_in_very_low_lead_exposed_pets:_a_community_study_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -